CpG islands are generally known as the epigenetic regulatory regions in accordance with histone modifications, methylation, and promoter activity. There is a significant need for the exact mapping of DNA methylation in CpG islands to understand the diverse biological functions. However, the precise identification of CpG islands from the whole genome through experimental and computational approaches is still challenging. Numerous computational methods are being developed to detect the CpG-enriched regions, effectively, to reduce the time and cost of the experiments. Here, we review some of the latest computational CpG detection methods that utilize clustering, patterns and physical-distance like parameters for CpG island detection. The comparative analyses of the methods relying on different principles and parameters allow prioritizing the algorithms for specific CpG associated datasets to achieve higher accuracy and sensitivity. A number of computational tools based on the window, Hidden Markov Model, density and distance-/length-based algorithms are being applied on human or mammalian genomes for accurate CpG detection. Comparative analyses of CpG island detection algorithms facilitate to prefer the method according to the target genome and required parameters to attain higher accuracy, specificity, and performance. There is still a need for efficient computational CpG detection methods with lower false-positive results. This review provides a better understanding about the principles of tools that will assist to prioritize and develop the algorithms for accurate CpG islands detection.

Rana Adnan Tahir

D A Zheng

Amina Nazir

Hong Qing

Journal of biosciences

《生物科学杂志》是班加罗尔印度科学院出版的季刊。它涵盖生物学的所有领域，是其范围内的国内一流期刊。它在当前目录和其他标准生物和医学数据库中被索引。 《生物科学杂志》始于 1934 年，当时是《印度科学院院刊》（B 部分）。这种情况一直持续到 1978 年，当时它被分为三个部分：PROCEEDINGS-ANIMAL SCIENCES、PROCEEDINGS-PLANT SCIENCES 和 PROCEEDINGS-EXPERIMENTAL BIOLOGY。 1979年PROCEEDINGS-EXPERIMENTAL BIOLOGY更名为JOURNAL OF BIOSCIENCES； 1991 年，PROCEEDINGS-ANIMAL SCIENCES 和 PROCEEDINGS-PLANT SCIENCES 与其合并。

The Journal of Biosciences is a quarterly publication by the Indian Academy of Sciences in Bangalore, covering all areas of biology and recognized as a leading national journal in its field. It is indexed in current directories and other standard biological and medical databases. The journal was established in 1934 as part of the Proceedings of the Indian Academy of Sciences (Section B). In 1978, it was divided into three sections: Proceedings-Animal Sciences, Proceedings-Plant Sciences, and Proceedings-Experimental Biology. In 1979, the Proceedings-Experimental Biology was renamed the Journal of Biosciences; in 1991, the Proceedings-Animal Sciences and Proceedings-Plant Sciences were merged into it.

《生物科学杂志》是由班加罗尔印度科学院出版的季刊，涵盖生物学的所有领域，是该领域内的国内一流期刊。该期刊在当前目录和其他标准生物与医学数据库中被广泛索引。《生物科学杂志》创刊于1934年，最初是《印度科学院院刊》（B部分）。1978年，该期刊分为三个部分：动物科学、植物科学和实验生物学。1979年，实验生物学部分更名为Journal of Biosciences；1991年，动物科学和植物科学部分与其合并。

Journal of Biosciences

J Biosci

A review of computational algorithms for CpG islands detection.

A review of the latest computational CpG detection methods that utilize clustering, patterns and physical-distance like parameters and a better understanding about the principles of tools that will assist to prioritize and develop the algorithms for accurate C pG islands detection is provided.

Category	Quartile
生物学	4
生物学, 生物学	4

A review of computational algorithms for CpG islands detection.

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