Cell migration triggered by pseudopodia (or "false feet") is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon. The decomposition of the deformation gradient is used to reproduce the cyclic phases of protrusion and contraction of the cell, which are tightly synchronized with the adhesion forces at the back and at the front of the cell, respectively. First, a steady active deformation is considered to show the ability of the cell to simultaneously initiate multiple pseudopodia. Here, randomness is considered as a key aspect, which controls both the direction and the amplitude of the false feet. Second, the migration process is described through two different strategies: the temporal and the spatial sensing models. In the temporal model, the cell "sniffs" the surroundings by extending several pseudopodia and only the one that receives a positive input will become the new leading edge, while the others retract. In the spatial model instead, the cell senses the external sources at different spots of the membrane and only protrudes one pseudopod in the direction of the most attractive one.

Rachele Allena

Bulletin of Mathematical Biology

BULLETIN OF MATHEMATICAL BIOLOGY 是数学生物学学会的官方期刊，传播原始研究成果和其他与生物学和数学科学接口相关的信息。贡献应该与这两个领域相关。为了适应广泛的新发展，该期刊接受各种投稿，包括：原创研究文章侧重于借助数学科学工具或新的数学工具和方法获得的新生物学见解，这些工具和方法已证明适用于生物学调查研究数学生物学教育评论评论观点，以及讨论对专业重要的问题的贡献所有贡献都经过同行评审。

The Bulletin of Mathematical Biology is the official journal of the Society for Mathematical Biology, dedicated to disseminating original research findings and information related to the interface between biology and mathematical sciences. Contributions should be relevant to both fields. The journal welcomes a variety of submissions, including original research articles that focus on new biological insights gained through mathematical tools or novel mathematical methods that have proven applicable to biological investigations; reviews on mathematical biology education; and discussions and viewpoints on issues of professional significance. All contributions undergo peer review.

《Bulletin of Mathematical Biology》是数学生物学学会的官方期刊，旨在传播原始研究成果及与生物学和数学科学交叉领域相关的信息。我们欢迎与这两个领域相关的各种投稿，包括：利用数学科学工具或新方法获得的新生物学见解的原创研究文章，这些工具和方法已被证明适用于生物学研究；数学生物学教育的评论；以及对专业重要问题的讨论和观点。所有投稿均经过同行评审。

Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models

A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon.

Category	Quartile
数学	4
数学, 生物学	4
数学, 数学与计算生物学	4

Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models

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