This study aimed to prepare and apply nanocapsules containing glycerol monolaurate for eradicating Streptococcus mutans biofilms. The interfacial deposition method of the preformed polymer synthesized the nanocapsules characterized for mean diameter, polydispersity index, zeta potential, pH, and morphology by transmission electron microscopy. The microdilution method investigated antimicrobial activity. Crystal violet staining determined biomass quantification and the ability to inhibit biofilm formation. The study also measured exopolysaccharide production and the number of viable colonies. The characterization outcomes indicated acceptable values for the mean diameter 198.1 ± 2, a polydispersity index of 0.087 ± 0.018, a zeta potential of -21.30 ± 2.00 mV, a pH of 6.19 ± 0.12, and typical nanostructure morphology. The evaluations of minimum inhibitory and bactericidal concentrations of glycerol monolaurate (free and nanoencapsulated) revealed their ineffectiveness in inhibiting microorganisms. Only free glycerol monolaurate inhibits S. mutans growth with 125 µg/mL. Biomass, exopolysaccharide content, and viable colonies in the biofilm were analyzed to assess the compounds' ability to inhibit biofilm formation. The tested compounds did not significantly reduce the formed biofilm. Despite unfavorable outcomes of the formulated preparation, further experimentation with a new formulation is encouraged to explore alternative strategies and potential improvements.

Leonardo Quintana Soares Lopes

Rodrigo de Almeida Vaucher

Janice Luehring Giongo

Patrícia Kolling Marquezan

Roberto Christ Vianna Santos

Bioscience Journal

BIOSCIENCE JOURNAL 是一份跨学科电子期刊，发表农业科学、生物科学和健康科学领域的科学文章。它的使命是传播新知识，同时为国家和世界的科学发展做出贡献。该杂志以英文连续出版。发表的文章中表达的观点和概念是其作者的唯一责任。

The Bioscience Journal is an interdisciplinary electronic journal that publishes scientific articles in the fields of agricultural science, biological science, and health science. Its mission is to disseminate new knowledge and contribute to scientific development both nationally and globally. The journal is published continuously in English, and the views and concepts expressed in the published articles are solely the responsibility of the authors.

《Bioscience Journal》是一份跨学科的电子期刊，专注于农业科学、生物科学和健康科学领域的研究文章。其使命是传播新知识，并为国家和全球的科学发展做出贡献。该期刊以英文持续出版，发表的文章中表达的观点和概念仅代表作者本人。

Category	Quartile
农林科学	4
农林科学, 农业综合	4
农林科学, 农艺学	4
农林科学, 生物学	4

Effect of glycerol monolaurate nanocapsules on Streptococcus mutans biofilm in vitro

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