This study analyzed the effect of mite-specific subcutaneous immunotherapy (SCIT) on patients with allergic rhinitis (AR). We enrolled 98 AR patients visiting our hospital from April 2017 to April 2019 and grouped them in a random number table. The control group (n=49) received conventional treatment for three years. The SCIT used a standardized mite allergen injection for the experimental group (n=49) for three years. The study compared total nasal symptom score (TNSS), daily medication score (DMS), total combined score (TCS), visual analog scale (VAS) score, mini-rhinitis quality of life questionnaire (MiniRQLQ) score, and serum immunoglobulin E (sIgE) level before and after treatment. The overall response rate was higher in the experimental group than in the control group (59.18% vs. 30.61%, p&lt;0.05). After treatment, the experimental group had lower values for TCS and VAS score (p&lt;0.05); motion score; practical problems; nasal, ocular, and other symptoms (p&lt;0.05); and sIgE, Dermatophagoides pteronyssinus (Dp)-sIgE, and Dermatophagoides farinae (Df)-sIgE levels (p&lt;0.05) than the control group. The sIgE, Dp-sIgE, and Df-sIgE levels were lower in the effective group than in the ineffective group (p&lt;0.05). The areas under the ROC curves of IgE, Dp-sIgE, and Df-sIgE and their combination for predicting the therapeutic effect of mite-specific SCIT on AR were 0.839, 0.779, 0.814, and 0.903, respectively. Mite-specific SCIT relieved clinical symptoms and improved the quality of life of AR patients, probably by decreasing the IgE expression level.

Guoyan Sun

Shuangba He

Qingxiang Zhang

Bioscience Journal

BIOSCIENCE JOURNAL 是一份跨学科电子期刊，发表农业科学、生物科学和健康科学领域的科学文章。它的使命是传播新知识，同时为国家和世界的科学发展做出贡献。该杂志以英文连续出版。发表的文章中表达的观点和概念是其作者的唯一责任。

The Bioscience Journal is an interdisciplinary electronic journal that publishes scientific articles in the fields of agricultural science, biological science, and health science. Its mission is to disseminate new knowledge and contribute to scientific development both nationally and globally. The journal is published continuously in English, and the views and concepts expressed in the published articles are solely the responsibility of the authors.

《Bioscience Journal》是一份跨学科的电子期刊，专注于农业科学、生物科学和健康科学领域的研究文章。其使命是传播新知识，并为国家和全球的科学发展做出贡献。该期刊以英文持续出版，发表的文章中表达的观点和概念仅代表作者本人。

Category	Quartile
农林科学	4
农林科学, 农业综合	4
农林科学, 农艺学	4
农林科学, 生物学	4

Effect of mite-specific subcutaneous immunotherapy on patients with allergic rhinitis

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