Although several effective treatment modalities have been developed for cancers, the morbidity and mortality associated with cancer continues to increase every year. As one of the most exciting emerging technologies, protein microarrays represent a powerful tool in the field of cancer research because of their advantages such as high throughput, small sample usage, more flexibility, high sensitivity and direct readout of results. In this review, we focus on the research progress in four types of protein microarrays (proteome microarray, antibody microarray, lectin microarray and reversed protein array) with emphasis on their application in cancer research. Finally, we discuss the current challenges faced by protein microarrays and directions for future developments. We firmly believe that this novel systems biology research tool holds immense potential in cancer research and will become an irreplaceable tool in this field.

Guang Chen

Lina Yang

Guoxiang Liu

Yunfan Zhu

Fanghao Yang

Xiaolei Dong

Fenghua Xu

Feng Zhu

Can Cao

Di Zhong

Shuang Li

Huhu Zhang

Bing Li

PROTEOMICS - CLINICAL APPLICATIONS

蛋白质组学 - 临床应用已发展成为将蛋白质组学应用于人类疾病研究和临床转化领域的重要信息来源。该杂志每年出版 12 期，将在所有相关领域发表论文，包括：-旨在进一步了解人类疾病功能障碍的分子机制的基础蛋白质组学研究-致力于发现和验证诊断和预后疾病的蛋白质组学研究结果生物标志物——蛋白质组学用于发现新的药物靶点——蛋白质组学在药物开发过程中的应用——蛋白质组学作为临床试验的组成部分的应用。

Proteomics - Clinical Applications has become an important source of information for applying proteomics to human disease research and clinical translation. The journal publishes 12 issues annually, covering all relevant fields of research, including: - Basic proteomics studies aimed at further understanding the molecular mechanisms of human disease; - Proteomics research dedicated to discovering and validating biomarkers for diagnostic and prognostic diseases; - The application of proteomics in discovering new drug targets; - The role of proteomics in the drug development process; - The application of proteomics as part of clinical trials.

《Proteomics - Clinical Applications》已发展成为将蛋白质组学应用于人类疾病研究和临床转化领域的重要信息来源。该杂志每年出版12期，涵盖所有相关领域的研究，包括：- 基础蛋白质组学研究，旨在深入了解人类疾病的分子机制；- 发现和验证用于诊断和预后疾病的生物标志物的蛋白质组学研究；- 蛋白质组学在新药靶点发现中的应用；- 蛋白质组学在药物开发过程中的作用；- 蛋白质组学作为临床试验组成部分的应用。

Proteomics - Clinical Applications

Research progress in protein microarrays: Focussing on cancer research

This review focuses on the research progress in four types of protein microarrays (proteome micro array, antibody microarray, lectin microarray and reversed protein array) with emphasis on their application in cancer research.

Category	Quartile
生物学	4
生物学, 生化研究方法	4

Research progress in protein microarrays: Focussing on cancer research

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Journal Info

Category	Quartile
BIOCHEMICAL RESEARCH METHODS	3