A family of 40 terpenoid synthase genes ( AtTPS) was discovered by genome sequence analysis in Arabidopsis thaliana. This is the largest and most diverse group of TPS genes currently known for any species. AtTPS genes cluster into five phylogenetic subfamilies of the plant TPS superfamily. Surprisingly, thirty AtTPS closely resemble, in all aspects of gene architecture, sequence relatedness and phylogenetic placement, the genes for plant monoterpene synthases, sesquiterpene synthases or diterpene synthases of secondary metabolism. Rapid evolution of these AtTPS resulted from repeated gene duplication and sequence divergence with minor changes in gene architecture. In contrast, only two AtTPS genes have known functions in basic (primary) metabolism, namely gibberellin biosynthesis. This striking difference in rates of gene diversification in primary and secondary metabolism is relevant for an understanding of the evolution of terpenoid natural product diversity. Eight AtTPS genes are interrupted and are likely to be inactive pseudogenes. The localization of AtTPS genes on all five chromosomes reflects the dynamics of the Arabidopsis genome; however, several AtTPS genes are clustered and organized in tandem repeats. Furthermore, some AtTPS genes are localized with prenyltransferase genes ( AtGGPPS, geranylgeranyl diphosphate synthase) in contiguous genomic clusters encoding consecutive steps in terpenoid biosynthesis. The clustered organization may have implications for TPS gene evolution and the evolution of pathway segments for the synthesis of terpenoid natural products. Phylogenetic analyses highlight events in the divergence of the TPS paralogs and suggest orthologous genes and a model for the evolution of the TPS gene family.

S Aubourg

A Lecharny

J Bohlmann

Molecular genetics and genomics : MGG

分子遗传学和基因组学 (MGG) 发表同行评议的文章，涵盖遗传学和基因组学的所有领域。任何研究基因和基因组的方法都被考虑在内，无论是实验的、理论的还是合成的。 MGG 发表对遗传学、基因组学、生物学、医学和生物技术领域工作人员广泛感兴趣的所有生物的研究。该杂志调查了广泛的主题，包括最近几期的主题：延长寿命的机制生物体；筛选涉及线粒体功能的酵母金属稳态基因；稻瘟病菌品种特异性无毒基因的分子作图等。

Molecular Genetics and Genomics (MGG) publishes peer-reviewed articles covering all areas of genetics and genomics. We welcome any research methods related to genes and genomes, whether experimental, theoretical, or synthetic. The research published in this journal is of broad interest to professionals in genetics, genomics, biology, medicine, and biotechnology. The topics we explore are diverse, including recent themes such as mechanisms of lifespan extension; screening of yeast metal homeostasis genes involved in mitochondrial function; and molecular mapping of variety-specific avirulence genes in rice blast fungus.

《Molecular Genetics and Genomics》是一本发表同行评审文章的期刊，涵盖遗传学和基因组学的各个领域。我们欢迎任何研究基因和基因组的方法，无论是实验性的、理论性的还是合成性的。该期刊发表的研究对遗传学、基因组学、生物学、医学和生物技术领域的专业人士具有广泛的吸引力。我们探讨的主题范围广泛，包括最近几期的研究：延长寿命的机制；筛选与线粒体功能相关的酵母金属稳态基因；以及稻瘟病菌品种特异性无毒基因的分子作图等。

Molecular Genetics and Genomics

Mol Genet Genomics

Genomic analysis of the terpenoid synthase ( AtTPS) gene family of Arabidopsis thaliana.

Phylogenetic analyses highlight events in the divergence of the TPS paralogs and suggest orthologous genes and a model for the evolution of theTPS gene family.

Category	Quartile
生物学	3
生物学, 生化与分子生物学	3
生物学, 遗传学	3

Genomic analysis of the terpenoid synthase ( AtTPS) gene family of Arabidopsis thaliana.

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Journal Info

Category	Quartile
GENETICS & HEREDITY	3