Background: The timely initiation of lactogenesis II is crucial for postpartum women, with delays having significant clinical implications. This study aimed to evaluate the determinants of delayed lactogenesis II (DOL II) in high-risk pregnant women to guide clinical interventions and postnatal care protocols. Methods: We conducted a study involving high-risk pregnant women who gave birth and were admitted to our hospital’'s obstetric intensive care unit for postpartum surveillance and treatment from February 1, 2023, to April 30, 2024. We utilized Pearson correlation analysis and logistic regression to determine factors linked to DOL II. Results: Our study included 206 high-risk pregnant women, with 85 (41.26%) experiencing DOL II. Pearson correlation analysis indicated strong associations between DOL II and maternal age (r = 0.452), gestational hypertension (r = 0.514), gestational diabetes (r = 0.487), and delayed colostrum secretion (r = 0.506), all statistically significant ( p &lt; 0.05). Logistic regression analysis identified age 35 years or older (OR = 2.115, 95%CI: 1.785–2.466), gestational hypertension (OR = 2.404, 95%CI: 2.125–3.107), gestational diabetes (OR = 2.556, 95%CI: 2.008–2.879), and colostrum secretion later than one hour postpartum (OR = 3.126, 95%CI: 2.682–3.605) as independent risk factors for DOL II, all with p &lt; 0.05. Conclusions: The incidence of DOL II is significantly elevated in high-risk pregnant women, especially those aged 35 or older, those with gestational diabetes and hypertension, and those who delay the initiation of breastfeeding. It is imperative that clinical practices prioritize enhanced prenatal care and health education, robust lactation support, and improved lactation awareness among postpartum women to reduce the prevalence of DOL II.

Qianqian Liu

Hanxiang Lin

Biological Research For Nursing

护理生物研究 (BRN) 是一份经过同行评审的季刊，可帮助护士研究人员、教育工作者和从业人员整合来自许多基础学科的信息；生物学、生理学、化学、卫生政策、商业、工程、教育、传播和社会科学进入护理研究、理论和临床实践。该期刊是出版伦理委员会 (COPE) 的成员

Biological Research for Nursing is a peer-reviewed quarterly journal designed to assist nurse researchers, educators, and practitioners in integrating information from various foundational disciplines, including biology, physiology, chemistry, health policy, business, engineering, education, communication, and social sciences, into nursing research, theory, and clinical practice. The journal is a member of the Committee on Publication Ethics (COPE).

《Biological Research for Nursing》是一本经过同行评审的季刊，旨在帮助护士研究人员、教育工作者和从业人员整合来自多个基础学科的信息，包括生物学、生理学、化学、卫生政策、商业、工程、教育、传播和社会科学，以促进护理研究、理论和临床实践的发展。该期刊是出版伦理委员会（COPE）的成员。

Category	Quartile
医学	4
医学, 护理	4

Delayed Lactogenesis II in High-Risk Pregnancies: What Should We Care

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