Abstract: Oxidative stress plays a central role in atherogenesis, implicated in endothelial dysfunc-tion, coronary plaque formation, and destabilization. Therefore, identifying oxidative stress in the vascular wall by reliable biomarkers could aid in early diagnosis and better coronary artery disease (CAD) prognostication. Because of the short half-life of reactive oxygen species, the current ap-proach is to measure stable products generated by the oxidation of macromolecules in plasma or urine. Most popular oxidative stress biomarkers are oxidized low-density lipoprotein, myeloperoxi-dase and lipid peroxidation biomarkers, such as malondialdehyde and F2-isoprostanes. Oxidative protein modification biomarkers and oxidized phospholipids have also been studied and discussed in the present review. Most of these biomarkers are associated with the presence and extent of CAD, are elevated in patients with acute coronary syndromes, and may predict outcomes independ-ent of traditional CAD risk factors. However, further standardization of measurement methods and assessment in large randomized clinical trials are required to integrate these biomarkers into clinical practice. In addition, evidence that these biomarkers detect oxidative stress in the vascular wall lacks and more specific biomarkers should be developed to identify vascular oxidative stress. Con-sequently, several oxidative stress biomarkers have been developed, most of which can be associat-ed with the presence and extent of CAD and event prognosis. However, they still have significant limitations that hinder their integration into clinical practice.

Spyridon Simantiris

Charalampos Papastamos

Alexios S. Antonopoulos

Panagiotis Theofilis

Marios Sagris

Martha Bounta

Georgia Konisti

Nikolaos Galiatsatos

Anna Xanthaki

Konstantinos Tsioufis

Dimitris Tousoulis

Current Topics in Medicinal Chemistry

CURRENT TOPICS IN MEDICINAL CHEMISTRY 是一个论坛，用于审查药物化学家和相关学科的其他人感兴趣的领域。每期仅针对特定主题，包含 6 到 9 篇评论，为读者提供对该领域的全面调查。一位特邀编辑，他是所审查主题的专家，将汇编每一期。药物化学当前主题的范围将涵盖药物化学的所有领域，包括合理药物设计、合成化学、生物有机化学、高通量筛选、组合化学、化合物多样性测量、药物吸收、药物分布、代谢、新的和新兴的药物靶点、天然产物、药物基因组学和构效关系。药物化学是一门迅速成熟的学科。研究结构和功能之间的关系对于理解生命的分子基础是绝对必要的。药物化学的当前主题旨在促进科学知识和洞察力的增长，并促进新治疗剂的发现和开发，以治疗使人衰弱的人类疾病。对于希望随时了解最新和最重要进展的每一位药物化学家来说，该杂志都是必不可少的。

Current Topics in Medicinal Chemistry is a forum dedicated to reviewing areas of interest for medicinal chemists and others in related disciplines. Each issue focuses on a specific topic and contains 6 to 9 review articles, providing readers with a comprehensive survey of the field. Each issue is compiled by a guest editor who is an expert in the reviewed topic. The scope of Current Topics in Medicinal Chemistry encompasses all areas of medicinal chemistry, including rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurement, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly evolving discipline, and understanding the relationship between structure and function is essential for grasping the molecular basis of life. The aim of Current Topics in Medicinal Chemistry is to foster the growth of scientific knowledge and insights and to facilitate the discovery and development of new therapeutic agents to combat debilitating human diseases. This journal is indispensable for every medicinal chemist who wishes to stay updated on the latest and most significant advancements.

《Current Topics in Medicinal Chemistry》是一个专门审查药物化学及相关学科领域的论坛。每期围绕特定主题，包含6到9篇评论文章，为读者提供该领域的全面调查。每一期由一位特邀编辑负责，他是所审查主题的专家。该期刊涵盖药物化学的各个领域，包括合理药物设计、合成化学、生物有机化学、高通量筛选、组合化学、化合物多样性测量、药物吸收、药物分布、代谢、新的和新兴的药物靶点、天然产物、药物基因组学和构效关系。药物化学是一门迅速发展的学科，研究结构与功能之间的关系对于理解生命的分子基础至关重要。《Current Topics in Medicinal Chemistry》的目标是促进科学知识和洞察力的增长，推动新治疗剂的发现与开发，以应对人类的重大疾病。对于希望了解最新和最重要进展的药物化学家而言，该杂志是必不可少的。

Oxidative Stress Biomarkers in Coronary Artery Disease

Several oxidative stress biomarkers have been developed, most of which can be associated with the presence and extent of CAD and event prognosis, however, they still have significant limitations that hinder their integration into clinical practice.

Category	Quartile
医学	4
医学, 药物化学	4

Oxidative Stress Biomarkers in Coronary Artery Disease

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