Background Glia represent a major cell population of the nervous system and they take part in virtually any process sustaining the development, the functioning and the pathology of the nervous system. Glial cells diversified significantly during evolution and distinct signals have been adopted to initiate glial development in mammals as compared to flies. In the invertebrate model Drosophila melanogaster, the transcription factor Gcm is necessary and sufficient to generate glial cells. Although Gcm orthologs have been found in protostomes and deuterostomes, they do not act in glial fate commitment as in flies, calling for further investigations of the evolutionarily conserved role of Gcm. Summary Here, we review the impact of the fly Gcm transcription factor in the differentiation of phagocytic competent cells inside and outside the nervous system, glia and macrophages respectively. Then, we discuss the evolutionary conservation of Gcm and the neural/non-neural functions of Gcm orthologs. Finally, we present a recent work from Pavlidaki et al. showing that the Gcm cascade is conserved from fly macrophages to mammalian microglia to counteract acute and chronic inflammation. Key Messages Gcm has an ancestral role in immunity and its anti-inflammatory effect is evolutionarily conserved. This opens new avenues to assess Gcm function in other species/animal models, its potential involvement in inflammation-related processes, such as regeneration, and to expand the investigation on glia evolution.

Sara Monticelli

Angela Giangrande

Brain Behavior and Evolution

《大脑、行为与进化》是一本拥有忠实追随者、高标准和独特形象的期刊，是关于神经系统进化的持续科学论述的主要渠道。该杂志发表比较神经生物学研究，重点关注脊椎动物和无脊椎动物的神经系统结构、功能或发育。方法范围从解剖学和生理学的分子到行为学。尽管存在这种多样性，但大多数发表在“大脑、行为和进化”上的论文都包含了进化的角度，至少在讨论中，并专注于神经机制或现象。一些纯粹的行为研究可能在期刊的范围内，但此类手稿的适用性将根据具体情况进行评估。该杂志还发表评论文章，提供对进化神经生物学当前主题的批判性概述。

Brain, Behavior and Evolution is a journal with a loyal readership, high standards, and a unique identity, primarily focused on the scientific discourse surrounding the evolution of the nervous system. The journal publishes comparative neurobiological research, emphasizing the structure, function, and development of the nervous systems of both vertebrates and invertebrates. The range of methodologies spans from anatomy and physiology to behavioral studies. Despite this diversity, most papers published in Brain, Behavior and Evolution incorporate an evolutionary perspective, emphasizing neural mechanisms or phenomena at least in the discussion. While some purely behavioral studies may fall within the journal's scope, the applicability of such manuscripts will be assessed on a case-by-case basis. Additionally, the journal publishes commentary articles that provide critical overviews of current topics in evolutionary neurobiology.

《Brain, Behavior and Evolution》是一本拥有忠实读者、高标准和独特形象的期刊，主要致力于神经系统进化的科学讨论。该期刊发表比较神经生物学的研究，重点关注脊椎动物和无脊椎动物的神经系统的结构、功能和发育。研究方法涵盖从解剖学和生理学到行为学的各个领域。尽管研究方法多样，但大多数发表在《Brain, Behavior and Evolution》上的论文都包含进化视角，至少在讨论中强调神经机制或现象。虽然一些纯粹的行为研究可能在期刊的范围内，但这些手稿的适用性将根据具体情况进行评估。此外，该期刊还发表评论文章，提供对当前进化神经生物学主题的批判性概述。

Category	Quartile
心理学	4
心理学, 行为科学	4
心理学, 神经科学	4
心理学, 动物学	4

Evolutionary conservation of the Gcm/Glide cascade: of glia and beyond

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info