Objective: To elucidate the anti-melanogenic potential of Carex pumila Thunb. extract (FBCC-EP850). Methods: A collection of 180 plant extracts was tested for inhibition of mushroom tyrosinase activity using an in vitro assay. Among them, FBCC-EP850 exhibited the most promising inhibitory activity. Further analysis was conducted to investigate its mechanisms and therapeutic potential in reducing melanogenesis in B16F10 melanoma cells and zebrafish larvae. Results: FBCC-EP850 inhibited mushroom tyrosinase activity in a dose-dependent manner, with a half-maximal inhibitory concentration of 45.83 μg/mL. FBCC-EP850 at concentrations up to 50 pg/mL demonstrated minimal cytotoxicity against B16F10 melanoma cells and no adverse effects on zebrafish larvae. Treatment with 50 μg/mL of FBCC-EP850 significantly reduced α-melanocyte stimulating hormone-induced melanin production and suppressed cellular tyrosinase activity in B16F10 melanoma cells. Additionally, FBCC-EP850 at 25 and 50 μg/mL effectively diminished hyperpigmentation in α-melanocyte stimulating hormone-stimulated zebrafish larvae. Its anti-melanogenic action could be attributed to modulation of the cAMP-CREB-MITF signaling pathway. Conclusions: Carex pumila extract can inhibit melanogenesis by modulating the cAMP-CREB-MITF signaling pathway, which can be used as a promising candidate for treating hyperpigmentation disorders.

Mirissa Hewage Dumindu Kavinda

Jinkuk Park

Nayeong Kim

Yung Hyun Choi

Gi-Young Kim

Asian Pacific Journal of Tropical Biomedicine

该杂志将涵盖生物​​学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业。具有临床意义和意义的文章将被优先考虑。

The Asian Pacific Journal of Tropical Biomedicine covers a wide range of fields including biology, bacteriology, biochemistry, biotechnology, cell biology, environmental biology, microbiology, medical microbiology, pharmacology, physiology, pathology, immunology, virology, toxicology, epidemiology, vaccinology, hematology, histopathology, cytology, genetics, and tropical agriculture. Articles with clinical significance and importance will be given priority.

《Asian Pacific Journal of Tropical Biomedicine》涵盖生物学、细菌学、生物化学、生物技术、细胞生物学、环境生物学、微生物学、医学微生物学、药理学、生理学、病理学、免疫学、病毒学、毒理学、流行病学、疫苗学、血液学、组织病理学、细胞学、遗传学和热带农业等领域。具有临床意义和重要性的文章将优先考虑。

Category	Quartile
医学	4
医学, 热带医学	4

Anti–melanogenic properties of FBCC–EP850 derived from Carex pumila Thunb

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Category	Quartile
TROPICAL MEDICINE	3