Background Iatrogenic withdrawal syndrome is a well-known adverse effect of sedatives and analgesics commonly used in patients receiving mechanical ventilation in the pediatric intensive care unit, with an incidence of up to 64.6%. When standard sedative and analgesic treatment is inadequate, dexmedetomidine may be added. The effect of supplemental dexmedetomidine on iatrogenic withdrawal syndrome is unclear. Objective To explore the potentially preventive effect of dexmedetomidine, used as a supplement to standard morphine and midazolam regimens, on the development of iatrogenic withdrawal syndrome in patients receiving mechanical ventilation in the pediatric intensive care unit. Methods This retrospective observational study used data from patients on a 10-bed general pediatric intensive care unit. Iatrogenic withdrawal syndrome was measured using the Sophia Observation withdrawal Symptoms-scale. Results In a sample of 102 patients, the cumulative dose of dexmedetomidine had no preventive effect on the development of iatrogenic withdrawal syndrome (P = .19). After correction for the imbalance in the baseline characteristics between patients who did and did not receive dexmedetomidine, the cumulative dose of midazolam was found to be a significant risk factor for iatrogenic withdrawal syndrome (P &amp;lt; .03). Conclusion In this study, supplemental dexmedetomidine had no preventive effect on iatrogenic withdrawal syndrome in patients receiving sedative treatment in the pediatric intensive care unit. The cumulative dose of midazolam was a significant risk factor for iatrogenic withdrawal syndrome.

Barbara M. Geven

Jolanda M. Maaskant

Catherine S. Ward

Job B.M. van Woensel

Critical Care Nurse

重症监护护士 (CCN) 是美国重症监护护士协会 (AACN) 的官方出版物。邀请作者提交手稿以供考虑和同行评审。临床主题必须符合 CCN 的使命，并解决急危重症患者的护理实践。

Critical Care Nurse is the official publication of the American Association of Critical-Care Nurses (AACN). We invite authors to submit manuscripts for consideration and peer review. Clinical topics must align with the mission of Critical Care Nurse and address the nursing practice for critically ill patients.

《Critical Care Nurse》是美国重症监护护士协会（AACN）的官方出版物。我们欢迎作者提交手稿以供考虑和同行评审。临床主题必须符合《Critical Care Nurse》的使命，并关注急危重症患者的护理实践。

Category	Quartile
医学	4
医学, 危重病医学	4
医学, 护理	4

Dexmedetomidine and Iatrogenic Withdrawal Syndrome in Critically Ill Children

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