Introduction: A series of novel 2-((3,5-diphenylpyrazin-2-yl)amino)-1-(piperidin-1- yl/pyrrolidin-1-yl)ethanone derivatives (5a-5l) were synthesized and evaluated for their tuberculosis activity using the standard strain H37Rv and two other clinically isolated multidrug-resistant strains with different resistances. Method: All compounds 5a-5l showed promising results in tuberculosis activity. Among them, 5g and 5i demonstrated remarkable activity at 5 μg/mL against H37Rv and three other MDR strains. The compounds 5c, 5d, and 5f were sensitive, showing inhibition between 15-25 μg/mL against M. tuberculosis growth. In-silico docking studies were conducted for 5a-5l using the 2FUM protein of M. tuberculosis. Result: These studies revealed that compounds 5g and 5i exhibited strong interactions with the MTB protein, with binding energies of -9.85 kcal/mol and -10.74 kcal/mol, respectively, and inhibitory concentrations of 0.38 μM and 0.77 μM. Conclusion: Moreover, these motifs also displayed good binding energy coupled with favorable minimum inhibitory concentrations (MIC).

Nagaraja Reddy Gangarapu

A Ranganatham

Eeda Koti Reddy

Chakka Kiran Kumar

Shivaraj Yellappa

Kothapalli Bannoth Chandrasekhar

Elanchezhiyan Manickan

Medicinal Chemistry

AIMS & SCOPEMEDICINAL CHEMISTRY 是一本同行评审期刊，旨在涵盖药物化学和合理药物设计方面的所有最新杰出发展。该杂志发表原创研究、小型评论文章和客座编辑的主题问题，涵盖该领域的最新研究和发展。通过充分利用互联网技术进行稿件投稿和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的人的重要期刊。

Medicinal Chemistry is a peer-reviewed journal aimed at covering all the latest outstanding developments in the fields of medicinal chemistry and rational drug design. The journal publishes original research, short review articles, and themed issues edited by guest editors, encompassing the latest research and advancements in the field. By fully utilizing internet technology for manuscript submission and peer review, articles are published rapidly. Medicinal Chemistry is an essential journal for all those involved in drug design and discovery.

《Medicinal Chemistry》是一本经过同行评审的期刊，旨在涵盖药物化学和合理药物设计领域的最新杰出进展。该期刊发表原创研究、小型评论文章以及客座编辑的主题专刊，涉及该领域的最新研究和发展。通过充分利用互联网技术进行稿件提交和同行评审，文章得以快速发表。药物化学是所有参与药物设计和发现的研究人员的重要期刊。

Category	Quartile
医学	4
医学, 药物化学	4

Synthesis, Docking, and Biological Studies of Pyrazine Derivatives as Antimycobacterial Agents

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	3