Background: Preeclampsia is a pregnancy-specific disease, which is easy to cause adverse outcomes in mother and child. Effective prediction of preeclampsia have important clinic al significance. This retrospective study aimed to investigate the utility of thrombin time during the first trimester as a predictive marker for preeclampsia. Methods: We meticulously examined the clinical characteristics of a cohort comprising 222 pregnant individuals with mild preeclampsia, 315 with severe preeclampsia, and 396 healthy pregnant women. Subsequently, we conducted both univariate and multiple regression analyses to discern variations in quantitative variables across these groups and to ascertain any discernible associations between thrombin time and the incidence of preeclampsia. Furthermore, we assessed the predictive performance of thrombin time by utilizing the receiver-operating characteristic (ROC) area under the curve (AUC). Results: Thrombin time exhibited a statistically significant prolongation in the preeclampsia cohort compared to the healthy pregnancy cohort (p &lt; 0.05). This significance was maintained after adjusting for maternal age and gestation at testing in the logistic regression model. The AUC for thrombin time was found to be 0.953, with a commendable specificity of 97.28% and sensitivity of 92.48% in predicting preeclampsia. Conclusions: Our findings provide compelling evidence of a noteworthy association between prolonged thrombin time in the first trimester and an elevated risk of preeclampsia. The robust positive correlation underscores the potential of prolonged thrombin time as a predictive marker for the development of preeclampsia. Nevertheless, it is crucial to emphasize that further experimental studies are imperative to elucidate the underlying pathogenesis of thrombin time in the progression of preeclampsia.

Yuting Li

Yanli Chen

Hua Shu

Xiaoyun Zhang

Peng Li

Fengge Wang

Dongmei Man

Clinical and Experimental Obstetrics & Gynecology

CEOG is an international, peer-reviewed, open access journal. CEOG covers all aspects of Obstetrics and Gynecology, including obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine. All submissions of cutting-edge advances of medical research in the area of women's health worldwide are encouraged.

Clinical and Experimental Obstetrics and Gynecology is an international, peer-reviewed, open access journal. It covers all aspects of Obstetrics and Gynecology, including obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, and sexual medicine. We encourage submissions of cutting-edge medical research advances in the field of women's health worldwide.

《Clinical and Experimental Obstetrics and Gynecology》是一本国际性的、经过同行评审的开放获取期刊。该期刊涵盖了妇产科的各个方面，包括产科、产前诊断、母胎医学、围产医学、普通妇科、妇科肿瘤学、泌尿妇科、生殖医学、不孕症、生殖内分泌学和性医学。我们鼓励全球范围内在女性健康领域的前沿医学研究的所有投稿。

Category	Quartile
医学	4
医学, 妇产科学	4

Predictive Value of Thrombin Time in Early Preeclampsia

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Category	Quartile
OBSTETRICS & GYNECOLOGY	4