Baghdadite (BAG, Ca 3 ZrSi 2 O 9 ), a calcium silicate compound with zirconium incorporation, shows significant potential in medical implants. However, its susceptibility to infections poses a considerable challenge. To tackle this problem, doping biocompatible magnesium (Mg) into BAG to create Mg‐BAG enhances antibacterial activity and prevents infection in orthopedic implants. Mg‐BAG demonstrates effectiveness against Gram‐positive Staphylococcus aureus and Gram‐negative Pseudomonas aeruginosa . This study finds that the antibacterial activity of Mg‐BAG is multifaced including causing the generation of reactive oxygen species (ROS) within cells and disrupting membrane potential, resulting in leakage of intracellular contents. The synchrotron macro attenuated total reflectance Fourier‐transform infrared microspectroscopy shows the impact of Mg‐BAG on bacteria, resulting in modifications to biomolecules such as lipids, protein structures, and the stability of nucleic acids. The combined effect of Mg ions (Mg 2+ ) and intracellular ROS formation contributes to the disruption of biomolecules and bacterial cell death. Mg‐BAG is a promising next‐generation bioceramic offering innovative nonantibiotic solutions for preventing infection.

Huu Ngoc Nguyen

Iman Roohani

Andrew Hayles

Zufu Lu

Jitraporn Vongsvivut

Krasimir Vasilev

Vi Khanh Truong

Hala Zreiqat

Advanced NanoBiomed Research

Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.

 

The scope of Advanced NanoBiomed Research will cover the following key subject areas:

▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.

▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.

▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.

▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.

▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.

▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.

 

with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.

Advanced NanoBiomed Research will provide an Open Access platform for cutting-edge research in nanomedicine, bioengineering, and biomaterials aimed at improving human health. The journal will encompass a wide range of research from increasingly multi- and interdisciplinary fields within traditional areas of biomedicine, bioengineering, and health-related materials science, as well as precision medicine, personalized medicine, drug delivery, and artificial intelligence-driven health science.\n\nThe scope of Advanced NanoBiomed Research will cover the following key subject areas: \n\n▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy, and multimodal imaging.\n\n▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids, and biomimetics (such as artificial cells, exosomes, and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.\n\n▪ Biointerfaces, such as antimicrobial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering, and 3D cell culture.\n\n▪ Biofabrication, including (bio)inks and technologies aimed at generating functional tissues and organs.\n\n▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches for bone, ligament, muscle, skin, neural, and cardiac tissue engineering, as well as tissue vascularization.\n\n▪ Devices for healthcare applications, disease modeling, and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.\n\nWith a strong focus on the applications of these fields, from bench to bedside, the journal aims to address the treatment of all diseases and disorders, including infectious diseases, autoimmune diseases, cardiovascular and metabolic diseases, neurological disorders, and cancer; including pharmacology and toxicology studies.

《Advanced NanoBiomed Research》将为前沿的纳米医学、生物工程和生物材料研究提供一个开放获取的平台，旨在改善人类健康。该期刊将涵盖来自生物医学、生物工程和健康相关材料科学等传统领域的多学科和跨学科研究，以及精准医疗、个性化医疗、药物递送和人工智能驱动的健康科学等广泛主题。\n\n《Advanced NanoBiomed Research》的主要研究领域包括：\n\n▪ 纳米医学和纳米技术，应用于药物和基因递送、诊断、治疗诊断、光热和光动力疗法以及多模态成像。\n\n▪ 生物材料，包括水凝胶、二维材料、生物聚合物、复合材料、可生物降解材料、生物混合材料和仿生材料（如人工细胞、外泌体和细胞外囊泡），以及所有用于生物医学应用的有机和无机材料。\n\n▪ 生物界面，如抗微生物表面和涂层，以及用于细胞工程、免疫工程和三维细胞培养的界面。\n\n▪ 生物制造，包括（生物）墨水和技术，旨在生成功能性组织和器官。\n\n▪ 组织工程和再生医学，包括支架和无支架方法，用于骨、韧带、肌肉、皮肤、神经和心脏组织工程及组织血管化。\n\n▪ 用于医疗应用的设备、疾病建模和治疗，如诊断、芯片实验室、器官芯片、生物微机电系统、生物电子设备、可穿戴设备、执行器、软机器人和智能药物递送系统。\n\n该期刊将重点关注这些领域的应用，从实验室到临床，为各种疾病和障碍的治疗提供解决方案，包括传染病、自身免疫病、心血管和代谢疾病、神经系统疾病和癌症；同时包括药理学和毒理学研究。

Antibacterial Activity and Mechanisms of Magnesium‐Doped Baghdadite Bioceramics for Orthopedic Implants

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Journal Info

Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	2