The unicellular parasitic protozoan Trichomonas vaginalis causes trichomoniasis, the most prevalent nonviral sexually transmitted disease globally. T. vaginalis evades host immune responses by producing homologs of host proteins, including cytokines such as macrophage migration inhibitory factor. T. vaginalis macrophage migration inhibitory factor ( Tv MIF) helps to facilitate the survival of T. vaginalis during nutritional stress conditions, increases prostate cell proliferation and invasiveness, and induces inflammation-related cellular pathways, thus mimicking the ability of human MIF to increase inflammation and cell proliferation. The production, crystallization and three structures of N-terminally hexahistidine-tagged Tv MIF reveal a prototypical MIF trimer with a topology similar to that of human homologs (hMIF-1 and hMIF-2). The N-terminal tag obscures the expected pyruvate-binding site. The similarity of Tv MIF to its human homologs can be exploited for structure-based drug discovery.

Aruesha Srivastava

Aryana Nair

Omolara C. O. Dawson

Raymond Gao

Lijun Liu

Justin K. Craig

Kevin P. Battaile

Elizabeth K. Harmon

Lynn K. Barrett

Wesley C. Van Voorhis

Sandhya Subramanian

Peter J. Myler

Scott Lovell

Oluwatoyin A. Asojo

Rabih Darwiche

Acta Crystallographica Section F Structural Biology Communications

ACTA CRYSTALLOGRAPHICA SECTION F 是一本快速结构生物学通讯期刊。该期刊欢迎有关结构生物学任何方面的文章，包括使用高通量方法确定的结构或来自诸如制药行业使用的迭代研究的结构。该期刊提供开放访问选项和所有通信都受益于无限制免费使用彩色插图且不收取页面费用。鼓励作者提交多媒体内容以与他们的文章一起发表。ACTA CRYST。 F 有一个名为 PUBLBIO 的专用在线工具，旨在使作者更轻松地准备和提交文章。

Acta Crystallographica Section F: Structural Biology Communications is a rapid communications journal dedicated to structural biology research. The journal welcomes articles on all aspects of structural biology, including structures determined using high-throughput methods or those derived from iterative studies in the pharmaceutical industry. It offers open access options, and all communications benefit from unlimited free use of color illustrations without page charges. Authors are encouraged to submit multimedia content to accompany their articles. Additionally, Acta Crystallographica Section F provides a dedicated online tool called PUBLBIO, designed to assist authors in preparing and submitting their manuscripts more easily.

《Acta Crystallographica Section F: Structural Biology Communications》是一本快速发表结构生物学研究成果的通讯期刊。该期刊欢迎关于结构生物学各个方面的文章，包括使用高通量方法获得的结构，或来自制药行业的迭代研究所产生的结构。期刊提供开放获取选项，所有通信均可无限制免费使用彩色插图，且不收取页面费用。我们鼓励作者提交多媒体内容以与文章一同发表。此外，《Acta Crystallographica Section F》还提供名为PUBLBIO的专用在线工具，旨在帮助作者更轻松地准备和提交文章。

Acta Crystallographica Section F:Structural Biology Communications

Structures of <i>Trichomonas vaginalis</i> macrophage migratory inhibitory factor

<i>Trichomonas vaginalis</i>巨噬细胞移动抑制因子的结构

Category	Quartile
生物学	4
生物学, 生化研究方法	4
生物学, 生化与分子生物学	4
生物学, 生物物理	4
生物学, 晶体学	4

Structures of Trichomonas vaginalis macrophage migratory inhibitory factor

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info