Helicobacter pylori is one of the most common bacterial infections; over two-thirds of the world's population is infected by early childhood. Persistent H. pylori infection results in gastric ulcers and cancers. Due to drug resistance, there is a need to develop alternative treatments to clear H. pylori . The Seattle Structural Genomics Center for Infectious Disease (SSGCID) conducts structure–function analysis of potential therapeutic targets from H. pylori . Glutamyl-tRNA synthetase (GluRS) is essential for tRNA aminoacylation and is under investigation as a bacterial drug target. The SSGCID produced, crystallized and determined the apo structure of H. pylori GluRS ( Hp GluRS). Hp GluRS has the prototypical bacterial GluRS topology and has similar binding sites and tertiary structures to other bacterial GluRS that are promising drug targets. Residues involved in glutamate binding are well conserved in comparison with Pseudomonas aeruginosa GluRS ( Pa GluRS), which has been studied to develop promising new inhibitors for P. aeruginosa . These structural similarities can be exploited for drug discovery and repurposing to generate new antibacterials to clear persistent H. pylori infection and reduce gastric ulcers and cancer.

Dylan E. Davis

Jesuferanmi P. Ayanlade

David T. Laseinde

Sandhya Subramanian

Hannah Udell

Donald J. Lorimer

David M. Dranow

Thomas E. Edwards

Peter J. Myler

Oluwatoyin A. Asojo

Acta Crystallographica Section F Structural Biology Communications

ACTA CRYSTALLOGRAPHICA SECTION F 是一本快速结构生物学通讯期刊。该期刊欢迎有关结构生物学任何方面的文章，包括使用高通量方法确定的结构或来自诸如制药行业使用的迭代研究的结构。该期刊提供开放访问选项和所有通信都受益于无限制免费使用彩色插图且不收取页面费用。鼓励作者提交多媒体内容以与他们的文章一起发表。ACTA CRYST。 F 有一个名为 PUBLBIO 的专用在线工具，旨在使作者更轻松地准备和提交文章。

Acta Crystallographica Section F: Structural Biology Communications is a rapid communications journal dedicated to structural biology research. The journal welcomes articles on all aspects of structural biology, including structures determined using high-throughput methods or those derived from iterative studies in the pharmaceutical industry. It offers open access options, and all communications benefit from unlimited free use of color illustrations without page charges. Authors are encouraged to submit multimedia content to accompany their articles. Additionally, Acta Crystallographica Section F provides a dedicated online tool called PUBLBIO, designed to assist authors in preparing and submitting their manuscripts more easily.

《Acta Crystallographica Section F: Structural Biology Communications》是一本快速发表结构生物学研究成果的通讯期刊。该期刊欢迎关于结构生物学各个方面的文章，包括使用高通量方法获得的结构，或来自制药行业的迭代研究所产生的结构。期刊提供开放获取选项，所有通信均可无限制免费使用彩色插图，且不收取页面费用。我们鼓励作者提交多媒体内容以与文章一同发表。此外，《Acta Crystallographica Section F》还提供名为PUBLBIO的专用在线工具，旨在帮助作者更轻松地准备和提交文章。

Category	Quartile
生物学	4
生物学, 生化研究方法	4
生物学, 生化与分子生物学	4
生物学, 生物物理	4
生物学, 晶体学	4

Crystal structure of glutamyl-tRNA synthetase from Helicobacter pylori

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