Host response to viral infection is a highly regulated process involving engagement of various host factors, cytokines, chemokines, and stimulatory signals that pave the way for an antiviral immune response. The response is manifested in terms of viral sequestration, phagocytosis, and inhibition of genome replication, and, finally, if required, lymphocyte-mediated clearance of virally infected cells. During this process, cross-talk between viral and host factors can shape disease outcomes and immunopathology. Bone marrow stromal antigen 2 (BST-2), also know as tetherin, is induced by type I interferon produced in response to viral infections, as well as in certain cancers. BST-2 has been shown to be a host restriction factor of virus multiplication through its ability to physically tether budding virions and restrict viral spread. However, BST-2 has other roles in the host antiviral response. This review focuses on the diverse functions of BST-2 and its downstream signaling pathways in regulating host immune responses.

Ritudhwaj Tiwari

Juan C. de la Torre

Dorian B. McGavern

Debasis Nayak

DNA and Cell Biology

DNA 和细胞生物学针对分子和细胞生物学的各个方面提供权威的、经过同行评审的研究，并专注于结合机制和临床研究来推动该领域的发展。DNA 和细胞生物学的覆盖范围包括：基因结构、功能和调控基因调控细胞激活的分子机制基因表达的转录、翻译或表观遗传控制机制分子医学分子发病机制癌症和自身免疫性疾病的遗传途径细胞和分子生物学的转化研究细胞器自噬细胞凋亡P 体过氧化物酶体蛋白质生物合成和降解蛋白质合成的调节翻译后修饰控制降解细胞自主炎症和宿主细胞反应对感染的反应对细胞因子和其他生理介质的病原体的逃避途径。

The journal "DNA and Cell Biology" focuses on various aspects of molecular and cell biology, providing authoritative, peer-reviewed research. It aims to integrate mechanisms with clinical studies to advance the field. The scope includes: the structure, function, and regulation of genes; molecular mechanisms of gene regulation and cell activation; transcriptional, translational, or epigenetic control mechanisms of gene expression; molecular medicine; molecular pathogenesis; genetic pathways of cancer and autoimmune diseases; translational research in cell and molecular biology; autophagy and apoptosis of organelles; P bodies and peroxisomes; protein biosynthesis and degradation; regulation of protein synthesis; post-translational modifications; cellular degradation; autonomous inflammation and host cell responses to infection; and pathogen evasion pathways against cytokines and other physiological mediators.

《DNA and Cell Biology》期刊专注于分子和细胞生物学的各个方面，提供权威的、经过同行评审的研究。该期刊致力于结合机制与临床研究，推动该领域的发展。其覆盖范围包括：基因的结构、功能和调控；基因调控细胞激活的分子机制；基因表达的转录、翻译或表观遗传控制机制；分子医学；分子发病机制；癌症和自身免疫性疾病的遗传途径；细胞和分子生物学的转化研究；细胞器的自噬与凋亡；P体和过氧化物酶体；蛋白质的生物合成与降解；蛋白质合成的调节；翻译后修饰；细胞的降解；自主炎症及宿主细胞对感染的反应；以及对细胞因子和其他生理介质的病原体逃避途径。

Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (<i>BST-2</i>)

BST-2 has been shown to be a host restriction factor of virus multiplication through its ability to physically tether budding virions and restrict viral spread, but has other roles in the host antiviral response.

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4
生物学, 细胞生物学	4
生物学, 遗传学	4

Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (BST-2)

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Journal Info

Category	Quartile
GENETICS & HEREDITY	2