Abstract Although surface-enhanced Raman spectroscopy (SERS) is a powerful analytical technique with unbeaten sensitivity, the capabilities of SERS have been not fully utilized in screening applications because throughput of spectrum detection by conventional Raman instruments has been restricted due to their single-point measurement manners. Hence, this paper presents a development of a high throughput Raman screening system that employs a fiber-optic switch and a Raman probe array. In the system, a 785 nm excitation light is directed into the 1 × 8 broadband optical switching device and selectively switched to one of 8 output ports connected to the corresponding Raman probe array to deliver the light to samples under each probe. This optical switching driven probing in sequence allows us to rapidly detect Raman scattering of the multiple ( n = 8) samples in array within a short time (~ 28 s) with decent sensitivity (10 –7 M). The Raman spectroscopy of the system is validated by comparing the features of Raman spectra obtained from vitamin C tablets with those from a commercial Raman microscope and the detection sensitivity is measured with SERS substrates with different concentrations. Then, feasibility of high throughput screening is tested with a SERS chip array.

Seung-Jin Lee

Kwan Hee Lee

Young-Wan Choi

Jun Ki Kim

Woo June Choi

BioChip Journal

BIOCHIP JOURNAL 发表以下学科生物芯片技术所有领域的原创研究和评论，包括蛋白质芯片、DNA 芯片、细胞芯片、芯片实验室、生物 MEMS、生物传感器、微/纳米力学、微流体、高通量筛选技术、医学科学、基因组学、蛋白质组学、生物信息学、医学诊断学、环境监测和微/纳米技术。该杂志致力于快速同行评审，以确保发表最高质量的原创研究和及时的新闻和评论文章。

The Biochip Journal publishes original research and reviews in all areas of biochip technology, including protein chips, DNA chips, cell chips, lab-on-a-chip, bio-MEMS, biosensors, micro/nano mechanics, microfluidics, high-throughput screening technologies, medical sciences, genomics, proteomics, bioinformatics, medical diagnostics, environmental monitoring, and micro/nano technologies. The journal is committed to rapid peer review to ensure the publication of high-quality original research and timely news and review articles.

《Biochip Journal》发表生物芯片技术各领域的原创研究和评论，包括蛋白质芯片、DNA芯片、细胞芯片、芯片实验室、生物MEMS、生物传感器、微/纳米力学、微流体、高通量筛选技术、医学科学、基因组学、蛋白质组学、生物信息学、医学诊断学、环境监测以及微/纳米技术。该杂志致力于快速同行评审，以确保发表最高质量的原创研究和及时的新闻与评论文章。

Category	Quartile
工程技术	3
工程技术, 生化研究方法	3
工程技术, 分析化学	3
工程技术, 纳米科技	4

Optical-Switch Raman Spectroscopy for High Throughput Screening

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Journal Info

Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	2