Diacylglycerol (DAG) is a relatively simple and primitive form of lipid, which does not possess a phospholipid headgroup. Being a central metabolite of the lipid metabolism network, DAGs are omnipresent in all life forms. While the role of DAG has been established in membrane and storage lipid biogenesis, it can impart crucial physiological functions including membrane shapeshifting, regulation of membrane protein activity and transduction of cellular signalling as a lipid-based secondary messenger. Besides, the chemical diversity of DAGs, due to fatty acyl chain composition, has been proposed to be the basis of its functional diversity. Therefore, cells must regulate DAG level at a spatio-temporal scale for homeostasis and adaptation. The vast network of eukaryotic lipid metabolism has been unravelled majorly by studying yeast models. Here, we review the current understanding and the emerging concepts in metabolic and functional aspects of DAG regulation in yeast. The implications can be extended to understand pathogenic fungi and mammalian counterparts as well as disease aetiology.

Sudipta Mondal

Biswajit Pal

Rajan Sankaranarayanan

FEMS Yeast Research

FEMS YEAST RESEARCH 提供高质量原创研究文章、小型评论、致编辑的信函、观点和评论的高效出版，表达当前观点。该期刊将仅选择那些被认为与该领域具有重要相关性的手稿进行出版，并且通常不会考虑那些在很大程度上描述性而没有对潜在机制或生物学的见解的文章。欢迎提交任何酵母品种，只要它们报告的结果在下面概述的范围内并且对酵母领域具有重要意义。

FEMS Yeast Research is a high-quality academic journal that efficiently publishes original research articles, short reviews, letters to the editor, viewpoints, and commentaries. The journal only accepts manuscripts that are deemed to have significant relevance to the field of yeast research and typically does not consider articles that are largely descriptive without insights into potential mechanisms or biology. We welcome submissions on any yeast strains, provided that the reported results are within the scope outlined below and are of significant importance to the field of yeast research.

FEMS Yeast Research 是一本高质量的学术期刊，专注于原创研究文章、小型评论、致编辑的信函、观点和评论的高效出版。该期刊仅接受那些与酵母研究领域具有重要相关性的手稿，通常不考虑那些主要描述性且缺乏对潜在机制或生物学见解的文章。我们欢迎提交任何酵母品种的研究，只要其结果在本期刊的范围内，并对酵母领域具有重要意义。

Category	Quartile
生物学	4
生物学, 生物工程与应用微生物	4
生物学, 微生物学	4
生物学, 真菌学	4

Diacylglycerol metabolism and homeostasis in fungal physiology

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