We aimed to determine the influence of ischemic heart disease (IHD) and cardiac rehabilitation (CR) on cerebrovascular compliance index (Ci). Eleven (one female) patients with IHD (mean[SD]: 61[11] yr, 29[4] kg/m2) underwent 6 mo of CR, which consisted of ≥3 sessions/wk of aerobic and resistance training (20-60 min each). Ten (three female) similarly aged controls (CON) were tested at baseline as a comparator group. Middle cerebral artery velocity (MCAv) and mean arterial pressure were monitored continuously using transcranial Doppler ultrasound and finger photoplethysmography, respectively, during a rapid sit-to-stand maneuver. A Windkessel model was used to estimate cerebrovascular Ci every five cardiac cycles for a duration of 30 s. Cerebrovascular resistance was calculated as the quotient of MAP and MCAv. Two-way ANOVAs were used to determine whether cerebrovascular variables differ during postural transitions between groups and after CR. Baseline MCAv was higher in CON versus IHD (P = 0.014) and a time × group interaction was observed (P = 0.045) where MCAv decreased more in CON after standing. Compared with the precondition, CR had no effect on MCAv (condition P = 0.950) but a main effect of time indicated that MCAv decreased from the seated position in both conditions (time P = 0.013). Baseline cerebrovascular Ci was greater in IHD versus CON (P = 0.049) and the peak cerebrovascular Ci during the transition to standing was significantly higher in IHD compared with CON (interaction P = 0.047). CR did not affect cerebrovascular compliance (P = 0.452) and no time-by-condition interaction upon standing was present (P = 0.174). Baseline cerebrovascular Ci is higher in IHD at baseline compared with CON, but 6 mo of CR did not modify the transient increase in cerebrovascular Ci during sit-to-stand maneuvers.NEW & NOTEWORTHY Post-cardiac event cognitive impairment is common and exercise-based rehabilitation may be an effective intervention to mitigate cognitive decline. Microvascular damage due to high blood pressure pulsatility entering the brain is the putative mechanism of vascular dementia. Whether patients with ischemic heart disease exhibit lower cerebrovascular compliance, and if cardiac rehabilitation can improve cerebrovascular compliance is unknown. We observed that patients with ischemic heart disease have paradoxically higher cerebrovascular compliance, which is not affected by cardiac rehabilitation.

Geoff B. Coombs

Baraa K. Al-Khazraji

Neville Suskin

J. Kevin Shoemaker

Journal of Applied Physiology

《应用生理学杂志》发表了最高质量的原创研究和评论，研究了推动该领域发展的人类和动物的新型适应性和综合生理机制。该杂志鼓励提交检查各种器官、组织、细胞和/或分子途径对环境、生理和/或病理生理压力源的急性和适应性反应的手稿。作为应用生理学期刊，感兴趣的主题不限于特定的器官系统。因此，该杂志考虑了广泛的综合和转化研究主题，研究了疾病过程和缓解策略所涉及的机制，以及在整个生命周期中促进健康和福祉。优先考虑提供被认为对该领域产生影响的机械洞察力的手稿。

The Journal of Applied Physiology publishes high-quality original research and reviews that explore novel adaptive and integrative physiological mechanisms in humans and animals that drive advancements in the field. The journal encourages the submission of manuscripts examining the acute and adaptive responses of various organ, tissue, cellular, and/or molecular pathways to environmental, physiological, and/or pathophysiological stressors. As a journal in applied physiology, topics of interest are not limited to specific organ systems. Therefore, the journal considers a wide range of integrative and translational research topics that investigate the mechanisms involved in disease processes and mitigation strategies, as well as factors that promote health and well-being throughout the lifespan. Manuscripts providing mechanistic insights that are deemed impactful to the field are prioritized.

《Journal of Applied Physiology》发表高质量的原创研究和评论，探讨推动该领域发展的新型适应性和综合生理机制，涉及人类和动物的研究。该杂志鼓励提交手稿，研究各种器官、组织、细胞和分子途径对环境、生理和病理生理压力源的急性和适应性反应。作为应用生理学领域的期刊，感兴趣的主题不限于特定的器官系统。因此，该杂志考虑广泛的综合和转化研究主题，研究疾病过程和缓解策略所涉及的机制，以及促进健康和福祉的因素。优先考虑那些被认为对该领域产生重要影响的机械洞察力的手稿。

Impact of ischemic heart disease and cardiac rehabilitation on cerebrovascular compliance

Ci is higher in IHD at baseline compared to CON, but six months of CR did not modify the transient increase in cerebrovascular Ci during sit-to-stand maneuvers, and two-way ANOVAs were used to determine whether cerebroVascular variables differ during postural transitions between groups and after CR.

Category	Quartile
医学	3
医学, 生理学	2
医学, 运动科学	3

Impact of ischemic heart disease and cardiac rehabilitation on cerebrovascular compliance

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SPORT SCIENCES	1