The comprehensive advancement in DNA modification and coupling is driving DNA nanotechnology to new heights, paving the way for groundbreaking innovations in healthcare, materials science, and beyond. The ability to engineer DNA with tailored properties and functionalities underscores its immense potential in creating novel materials and devices. Utilizing a spectrum of techniques-such as amino handles, thiol groups, alkynes, azides, Diels-Alder reactions, hydrazides, and aminooxy functions-enables diverse coupling strategies, including Palladium-Catalyzed Couplings, to construct intricate DNA nanostructures. Further coupling modifications encompass hydrophobic alterations, redox-active moieties, chemical crosslinking agents, and Biotinylation. These modifications significantly broaden DNA's functional repertoire, offering precise control over interactions, structures, and features. By leveraging these advanced techniques, alongside next-generation sequencing (NGS)-based DNA modifications, researchers can design and implement DNA nanostructures with specific capabilities and applications, showcasing DNA's versatility as a programmable biomaterial. Through meticulous design and strategic implementation, DNA nanotechnology achieves unprecedented levels of precision and functionality, ushering in a new era of technological advancements and applications. These advanced DNA modification techniques hold great potential for transformative applications in nanotechnology, paving the way for innovations in drug delivery, diagnostics, and bioengineering.

Pratikeswar Panda

Rajaram Mohapatra

Nucleosides Nucleotides & Nucleic Acids

NUCLEOSIDES、NUCLEOTIDES & NUCLEIC ACIDS 发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学和生物学。这本全包期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

The journal "Nucleosides, Nucleotides and Nucleic Acids" publishes research articles, brief communications, and concise critical reviews on related topics, focusing on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. This comprehensive journal includes experimental details, emphasizing synthesis, bioactivity, new and improved synthetic methods, and significant observations related to new compounds.

《Nucleosides, Nucleotides and Nucleic Acids》期刊发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学与生物学。这本综合性期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4

Revolutionizing DNA: advanced modification techniques for next-gen nanotechnology

ivySCI AI Smartly Parses PDF, Answers Researchers' Questions, and Helps You Understand Papers in Seconds

Journal Info

Category	Quartile
BIOCHEMISTRY & MOLECULAR BIOLOGY	4