1. Nude is a new recessive gene causing hairlessness in the mouse. It is linked to rex and trembler in linkage group VII. The order of the three loci and the recombination frequencies are as follows: 2. In addition to hairlessness the new gene causes reduced body growth rate, very low fertility and a liver disease causing death. Nude mice may be classified at birth by the absence of vibrissae. 3. The hairlessness is due to abnormal keratinization of hair in the follicles. The skin histology resembles that of naked mice. The hair follicles were found to be deficient in free sulphydryl groups. 4. The majority of nude mice die of general body weakness within 2 weeks of birth. The survivors grow slowly and may live for a considerable period. But all nude mice eventually die, usually between 3 and 14 weeks of age. 5. The livers of dead or moribund nude mice are covered with lesions and scars. The defect has been traced histologically to its initial stage, namely, necrosis of small areas of tissue. 6. Attempts to relate the deficiency of sulphydryl groups in the hair follicles to abnormal sulphur metabolism in the liver were unsuccessful. 7. Pseudo-cysts of a parasitic protozoan, Toxoplasma gondii , were identified in the liver and brain of nude mice. In one case the free form of the organism was found. 8. The possible relationship between the liver disease and the pathogenic organism is discussed.

S. P. Flanagan

Genetics Research

Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.

Genetical Research is a key forum for original research on all aspects of human and animal genetics. It reports key findings on genomes, genes, mutations, and molecular interactions, extending to developmental, evolutionary, and population genetics, as well as ethical, legal, and social aspects. Our aim is to enhance the understanding of genetic processes in health and disease. The journal focuses on the application of new technologies, such as next-generation sequencing and bioinformatics analysis, to produce increasingly detailed insights into how genes function in tissues and how these genes operate, both individually and collectively, in normal development and disease etiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioral genetics, and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians, and researchers involved in the genetic basis of diseases, as well as evolutionary and developmental studies.

《Genetical Research》是一个重要的论坛，专注于人类和动物遗传学各个方面的原创研究，报道基因组、基因、突变和分子相互作用的关键发现，涵盖发育、进化和群体遗传学，以及伦理、法律和社会方面的问题。我们的目标是加深对健康和疾病中遗传过程的理解。期刊重点关注新技术的应用，如下一代测序和生物信息学分析，以提供越来越详细的视角，了解基因在组织中的功能，以及这些基因在正常发育和疾病病因中的表现，无论是单独还是集体。期刊发表原创研究、综述文章、短篇论文、计算研究以及涵盖人类和已建立遗传生物体的研究中的新方法和技术。主要研究领域包括医学遗传学、基因组学、人类进化和群体遗传学、生物信息学、复杂性状的遗传学、分子和发育遗传学、进化发育学、定量和统计遗传学、行为遗传学和环境遗传学。研究的广度和质量使得该期刊成为医学遗传学家、分子生物学家、生物信息学家以及从事疾病遗传基础、进化和发育研究的研究人员的重要资源。

Genetical Research

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

Nude is a new recessive gene causing hairlessness in the mouse and is linked to rex and trembler in linkage group VII, which causes reduced body growth rate, very low fertility and a liver disease causing death.

Category	Quartile
生物学	4
生物学, 遗传学	4

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

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Journal Info

Category	Quartile
GENETICS & HEREDITY	4