Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa).Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis.Methods: A risk model incorporating four ferroptosis-related genes was developed and validated.Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics.To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO).Moreover, we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays, as well as animal studies conducted in vivo.Additionally, we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis.Results: The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients.Mitogen-activated protein kinase 9 (MAPK9) emerged as a crucial gene within the model.In vivo and in vitro experiments explored MAPK9's role in ferroptosis and its influence on tumor migration and proliferation. Conclusion:The findings provide a novel perspective for advancing ferroptosis exploration in PCa, bridging basic research and clinical applications.

CHENG-GONG LUO

JIAO ZHANG

YUN-ZHAO AN

XUAN LIU

SHUAI-JIE LI

WEI ZHANG

KAI LI

XU ZHAO

DONG-BO YUAN

LING-YUE AN

WEI CHEN

YE TIAN

BIN XU

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BIOCELL 欢迎有关细胞和细胞成分的结构、功能和大分子组织的研究文章和评论文章，重点关注细胞动力学、运动和分化，特别是与细胞生物化学、分子生物学、免疫学、神经生物学以及亚组织和有机体方面有关的研究脊椎动物繁殖和发育，无脊椎动物生物学和植物生物学。

BIOCELL welcomes research articles and reviews on the structure, function, and macromolecular organization of cells and their components. We particularly focus on cell dynamics, movement, and differentiation, especially studies related to cell biochemistry, molecular biology, immunology, neurobiology, and the reproduction and development of vertebrates, invertebrates, and plant biology.

BIOCELL 欢迎关于细胞及其成分的结构、功能和大分子组织的研究和评论文章。我们特别关注细胞动力学、运动和分化，尤其是与细胞生物化学、分子生物学、免疫学、神经生物学以及脊椎动物和无脊椎动物的繁殖和发育、植物生物学相关的研究。

MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

MAPK9作为治疗靶点：揭示局部前列腺癌进展中的铁死亡

Category	Quartile
生物学	4
生物学, 生物学	4

MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

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