Abstract Cutaneous exposure to the DNA alkylating class of chemotherapeutic agents including nitrogen mustard (NM) leads to both skin injury and systemic inflammation. Circulating myeloid subsets recruited to the skin act to further exacerbate local tissue damage while interfering with the wound healing process. We demonstrate herein that intravenous delivery of p oly( l actic- co - g lycolic acid) i mmune- m odifying nano p articles (PLGA-IMPs) shortly after NM exposure restricts accumulation of macrophages and inflammatory monocytes at the injury site, resulting in attenuated skin pathology. Furthermore, PLGA-IMPs induce an early influx and local enrichment of Foxp3 + regulatory T cells (Treg) in the skin lesions critical for the suppression of myeloid cell-pro-inflammatory responses via induction of IL-10 and TGF-β in the cutaneous milieu. Functional depletion of CD4 + Tregs ablates the efficacy of PLGA-IMPs accompanied by a loss of local accumulation of anti-inflammatory cytokines essential for wound healing. Thus, in severe skin trauma, PLGA-IMPs may have therapeutic potential via modulation of inflammatory myeloid cells and regulatory T lymphocytes.

Ummiye V. Onay

Dan Xu

Dauren Biyashev

Spencer T. Evans

Michael M. Demczuk

Tobias Neef

Joseph R. Podojil

Sara Beddow

Nathan C. Gianneschi

I. Caroline Le Poole

Stephen D. Miller

Kurt Q. Lu

npj Regenerative Medicine

NPJ REGENERATIVE MEDICINE 是一本新的开放获取、仅限在线的期刊，致力于发表最高质量的研究，以帮助人体修复、替换、恢复和再生受损组织和器官。

NPJ Regenerative Medicine is a new open-access, online-only journal dedicated to publishing high-quality research aimed at facilitating the repair, replacement, restoration, and regeneration of damaged tissues and organs in the human body.

NPJ Regenerative Medicine 是一本新的开放获取、仅限在线的期刊，专注于发表高质量的研究，旨在促进人体对受损组织和器官的修复、替换、恢复和再生。

Category	Quartile
医学	1
医学, 工程生物医学	1
医学, 细胞与组织工程	2

Attenuation of skin injury by a MARCO targeting PLGA nanoparticle

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	1