Memories for events are thought to be represented in sparse, distributed neuronal ensembles (or engrams). In this article, we review how neurons are chosen to become part of a particular engram, via a process of neuronal allocation. Experiments in rodents indicate that eligible neurons compete for allocation to a given engram, with more excitable neurons winning this competition. Moreover, fluctuations in neuronal excitability determine how engrams interact, promoting either memory integration (via coallocation to overlapping engrams) or separation (via disallocation to nonoverlapping engrams). In parallel with rodent studies, recent findings in humans verify the importance of this memory integration process for linking memories that occur close in time or share related content. A deeper understanding of allocation promises to provide insights into the logic underlying how knowledge is normally organized in the brain and the disorders in which this process has gone awry.

Sheena A. Josselyn

Paul W. Frankland

Annual Review of Neuroscience

自 1978 年出版的《神经科学年度回顾》涵盖了整个神经科学领域的重大发展，包括分子和细胞神经科学、神经遗传学、发育、可塑性和修复、系统神经科学、认知神经科学、行为和疾病的神经生物学，以及偶尔回顾一下神经科学和伦理学的历史。

The Annual Review of Neuroscience, published since 1978, covers significant developments across the field of neuroscience, including molecular and cellular neuroscience, neurogenetics, development, plasticity and repair, systems neuroscience, cognitive neuroscience, the neurobiology of behavior and disease, and occasionally reviews the history of neuroscience and ethics.

《Annual Review of Neuroscience》自1978年出版，涵盖了神经科学领域的重大进展，包括分子和细胞神经科学、神经遗传学、发育、可塑性与修复、系统神经科学、认知神经科学、行为与疾病的神经生物学，以及偶尔回顾神经科学与伦理学的历史。

Memory Allocation: Mechanisms and Function

Experiments in rodents indicate that eligible neurons compete for allocation to a given engram, with more excitable neurons winning this competition, and fluctuations in neuronal excitability determine how engrams interact, promoting either memory integration or separation.

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医学	1
医学, 神经科学	1

Memory Allocation: Mechanisms and Function

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