Coronavirus disease 2019 (Covid-19) is a pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). In Covid-19, there is uncontrolled activation of immune cells with a massive release of pro-inflammatory cytokines and the development of cytokine storm. These inflammatory changes induce impairment of different organ functions, including the central nervous system (CNS), leading to acute brain injury and substantial changes in the neurotransmitters, including serotonin (5-HT) and calcitonin gene-related peptide (CGRP), which have immunomodulatory properties through modulation of central and peripheral immune responses. In Covid-19, 5-HT neurotransmitters and CGRP could contribute to abnormal and atypical vascular reactivity. Sumatriptan is a pre-synaptic 5-HT (5-HT1D and 5-HT1B) agonist and inhibits the release of CGRP. Both 5-HT and CGRP seem to be augmented in Covid-19 due to underlying activation of inflammatory signaling pathways and hyperinflammation. In virtue of its anti-inflammatory and antioxidant properties with inhibition release of 5-HT and CGRP, Sumatriptan may reduce Covid-19 hyperinflammation. Therefore, Sumatriptan might be a novel potential therapeutic strategy in managing Covid-19. In conclusion, Sumatriptan could be an effective therapeutic strategy in managing Covid-19 through modulation of 5-HT neurotransmitters and inhibiting CGRP.

Hayder M. Al-Kuraishy

Ali I. Al-Gareeb

Athanasios Alexiou

Nobendu Mukerjee

Sadiq Mohammed J. Al-Hamash

Thabat J. Al-Maiahy

Gaber El-Saber Batiha

Biotechnology and Genetic Engineering Reviews

《生物技术与基因工程评论》发表主要受邀评论文章，涵盖生物技术在工业、农业和医学应用方面的重要发展。

Biotechnology and Genetic Engineering Reviews primarily publishes invited review articles that cover significant advancements in the applications of biotechnology in industry, agriculture, and medicine.

《生物技术与基因工程评论》主要发表受邀的评论文章，涵盖生物技术在工业、农业和医学应用方面的重要进展。

5-HT/CGRP pathway and Sumatriptan role in Covid-19

Sumatriptan might be a novel potential therapeutic strategy in managing Covid-19 through modulation of 5-HT neurotransmitters and inhibiting CGRP because of its anti-inflammatory and antioxidant properties.

Category	Quartile
工程技术	3
工程技术, 生物工程与应用微生物	4
工程技术, 遗传学	4

5-HT/CGRP pathway and Sumatriptan role in Covid-19

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Journal Info

Category	Quartile
GENETICS & HEREDITY	1