Raman spectroscopy can detect conformational changes in collagen structures and these findings are reviewed in this article. More specifically, some progressive diseases are mainly caused by alterations of collagen molecules but what is occurring at the biochemical level of this complex molecule usually remains unclear. While it may be true that a number of analytical techniques can analyze collagen, most of them have a series of limitations that limit their applicability to a wide range of samples. To understand in more detail the progression of a disease due to changes in the collagen structure, a technique that can detect subtle alterations at the biochemical level is needed. Raman spectroscopy is a label-free and noninvasive technique that can easily pick up on any conformational changes reflected primarily at the lipids, amides and proline and hydroxyproline regions. This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understand changes in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.

Marcela Garcia Martinez

Anthony J. Bullock

Sheila MacNeil

Ihtesham U. Rehman

Applied Spectroscopy Reviews

应用光谱学评论提供有关光谱学所有不同分支的原理、方法和应用的最新信息，从 X 射线、红外、拉曼、原子吸收和 ESR 到微波、质量、NQR、NMR 和 ICP。这本国际单一来源期刊为化学家、物理学家和其他使用光谱技术的科学家提供了将物理概念与化学应用相关联的讨论。

The journal 'Applied Spectroscopy Reviews' provides the latest information on various branches of spectroscopy, including principles, methods, and applications. It covers a wide range of techniques from X-ray, infrared, Raman, atomic absorption, and electron spin resonance (ESR) to microwave, mass spectrometry, nuclear quadrupole resonance (NQR), nuclear magnetic resonance (NMR), and inductively coupled plasma (ICP). This international journal offers in-depth discussions for chemists, physicists, and other scientists who utilize spectroscopic techniques, linking physical concepts with chemical applications.

《Applied Spectroscopy Reviews》期刊提供关于光谱学各个分支的最新信息，包括原理、方法和应用，涵盖从X射线、红外、拉曼、原子吸收和电子自旋共振（ESR）到微波、质谱、核四极共振（NQR）、核磁共振（NMR）和感应耦合等离子体（ICP）等技术。这本国际性期刊为化学家、物理学家及其他使用光谱技术的科学家提供了将物理概念与化学应用相结合的深入讨论。

Characterisation of structural changes in collagen with Raman spectroscopy

This review is the first compilation of studies of conformational changes in collagen molecules, providing help to understandChanges in collagen biochemistry that can be of relevance to the human wound healing, ageing and pathologies.

Category	Quartile
化学	2
化学, 光谱学	1
化学, 仪器仪表	2

Characterisation of structural changes in collagen with Raman spectroscopy

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