Human amnion mesenchymal stem cells (HAMCs) show great differentiation and proliferation potential and also other remarkable features that could serve as an outstanding alternative source of stem cells in regenerative medicine. Recent reports have demonstrated various kinds of effective artificial niche that mimic the microenvironment of different types of stem cell to maintain and control their fate and function. The components of the stem cell microenvironment consist mainly of soluble and insoluble factors responsible for regulating stem cell differentiation and self-renewal. Extensive studies have been made on regulating HAMCs differentiation into specific phenotypes; however, the understanding of relevant factors in directing stem cell fate decisions in HAMCs remain underexplored. In this review, we have therefore identified soluble and insoluble factors, including mechanical stimuli and cues from the other supporting cells that are involved in directing HAMCs fate decisions. In order to strengthen the significance of understanding on the relevant factors involved in stem cell fate decisions, recent technologies developed to specifically mimic the microenvironments of specific cell lineages are also reviewed. Copyright © 2015 John Wiley & Sons, Ltd.

Sabanting Hednella Syva

Kamaruzaman Ampon

Helen Lasimbang

Simat Siti Fatimah

Journal of Tissue Engineering and Regenerative Medicine

《组织工程与再生医学杂志》迅速发表经过同行评审的研究论文、评论、临床病例报告、观点和简短的交流，讨论与开发结合干细胞或祖细胞、生物材料和支架、生长因子的治疗方法相关的主题和其他生物活性剂，以及它们各自的构建体。所有论文都应涉及对组织和器官再生或修复的新临床方法的开发具有直接或潜在影响的研究。该杂志是多学科的，涵盖生命科学和工程学原理的结合，以努力推进医学和临床策略。该杂志侧重于在开发恢复、维持或改善组织或器官功能的生物功能替代品中使用细胞、材料和生化/机械因素。该杂志发表关于任何组织或器官的研究，涵盖该领域的所有关键方面，包括新生物材料的开发和支架的加工；使用不同类型的细胞（主要是干细胞和祖细胞）及其在特定生物反应器中的培养；相关动物模型研究；在严格的监管和伦理框架下进行的人类患者临床试验。描述使用先进方法来表征工程组织的手稿也引起了期刊读者的特别兴趣。

The Journal of Tissue Engineering and Regenerative Medicine is dedicated to the rapid publication of peer-reviewed research papers, reviews, clinical case reports, viewpoints, and brief communications. It discusses topics related to therapeutic approaches involving stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents. All submissions should involve research that has direct or potential implications for the development of new clinical methods for tissue and organ regeneration or repair. This multidisciplinary journal integrates principles from life sciences and engineering to advance medical and clinical strategies. It particularly focuses on the use of cells, materials, and biochemical/mechanical factors in developing biological substitutes aimed at restoring, maintaining, or improving tissue or organ function. The journal welcomes research on any tissue or organ, covering all key aspects of the field, including the development of new biomaterials, scaffold fabrication, the use of various cell types (primarily stem and progenitor cells) and their culture in specific bioreactors, relevant animal model studies, and human clinical trials conducted under strict regulatory and ethical frameworks. Manuscripts that employ advanced methods to characterize engineered tissues are also of particular interest to the journal's readership.

《组织工程与再生医学杂志》致力于迅速发表经过同行评审的研究论文、评论、临床病例报告、观点和简短交流，讨论与干细胞或祖细胞、生物材料和支架、以及生长因子等治疗方法相关的主题。所有论文应涉及对组织和器官再生或修复的新临床方法的开发，具有直接或潜在的影响。该杂志是多学科的，结合生命科学和工程学原理，旨在推动医学和临床策略的发展。期刊特别关注在开发生物功能替代品以恢复、维持或改善组织或器官功能时，细胞、材料和生化/机械因素的应用。我们欢迎关于任何组织或器官的研究，涵盖该领域的所有关键方面，包括新生物材料的开发、支架的加工、不同类型细胞（主要是干细胞和祖细胞）的使用及其在特定生物反应器中的培养、相关动物模型研究，以及在严格监管和伦理框架下进行的人类临床试验。使用先进方法表征工程组织的手稿也特别受到期刊读者的关注。

Category	Quartile
生物学	3
生物学, 生物工程与应用微生物	3
生物学, 细胞与组织工程	4
生物学, 细胞生物学	4
生物学, 工程生物医学	4

Microenvironmental factors involved in human amnion mesenchymal stem cells fate decisions

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Journal Info

Category	Quartile
ENGINEERING, BIOMEDICAL	2