The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives. Novel drug modifications for overcoming these issues are under investigation and include covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid, as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres, polymeric nanoparticles). Such strategies have the potential to develop as next generation protein therapeutics. This review includes a general discussion on these delivery approaches.

Dipak S. Pisal

Matthew P. Kosloski

Sathy V. Balu-Iyer

Journal of Pharmaceutical Sciences

JOURNAL OF PHARMACEUTICAL SCIENCES 将发表原创研究论文、原创研究笔记、特邀专题评论（包括 MINIREVIEWS）以及社论评论和新闻。重点领域应为基础药物科学概念和药物化学加工等主题，包括结晶、冻干、药物化学稳定性、药代动力学、生物药剂学、药效学、前药开发、生物活性剂的代谢处置、剂型设计、蛋白质-肽化学和生物技术，特别是因为这些与制药技术和靶向药物输送有关。

The Journal of Pharmaceutical Sciences publishes original research articles, original research notes, invited topical reviews (including mini-reviews), as well as editorial comments and news. The focus areas should include fundamental concepts of pharmaceutical sciences and drug chemistry processing, covering topics such as crystallization, lyophilization, drug chemical stability, pharmacokinetics, biopharmaceutics, pharmacodynamics, prodrug development, metabolic disposition of bioactive agents, formulation design, protein-peptide chemistry, and biotechnology, particularly as they relate to pharmaceutical technology and targeted drug delivery.

《Journal of Pharmaceutical Sciences》将发表原创研究论文、研究笔记、特邀专题评论（包括小型综述）以及社论评论和新闻。重点领域包括基础药物科学概念和药物化学加工等主题，涵盖结晶、冻干、药物化学稳定性、药代动力学、生物药剂学、药效学、前药开发、生物活性剂的代谢处置、剂型设计、蛋白质-肽化学和生物技术，特别是与制药技术和靶向药物输送相关的研究。

Delivery of Therapeutic Proteins

This review includes a general discussion on covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres,polymeric nanoparticles).

Category	Quartile
医学	3
医学, 药物化学	3
医学, 化学综合	3
医学, 药学	3

Delivery of Therapeutic Proteins

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2