Human immunodeficiency virus (HIV), a type of lentivirus (a subgroup of retrovirus), causes acquired immunodeficiency syndrome (AIDS). This pathophysiologic state destroys the immune system allowing opportunistic infections, cancer and other life-threatening diseases to thrive. Although many analytic tools including enzyme-linked immunoassay (ELISA), indirect and line immunoassay, Western blotting, radio-immunoprecipitation, nucleic acid amplification testing (NAAT) have been developed to detect HIV, recent developments in nanosensor technology have prompted its use as a novel diagnostic approach. Nanosensors provide analytical information about behavior and characteristics of particles by using biochemical reactions mediated by enzymes, immune components, cells and tissues. These reactions are transformed into decipherable signals, i.e., electrical, thermal, optical, using nano to micro scale technology. Nanosensors are capable of both quantitative and qualitative detection of HIV, are highly specific and sensitive and provide rapid reproducible results. Nanosensor technology can trace infant infection during mother-to-child transmission, the latent HIV pool and monitor anti-HIV therapy. In this chapter, we review nanosensor analytics including electrochemical, optical, piezoelectric, SERS-based lateral flow assay, microfluidic channel-based biosensors in the detection of HIV. Other techniques in combination with different biorecognition elements (aptamers, antibodies, oligonucleotides) are also discussed.

Sarthak Nandi

Ayusi Mondal

Akanksha Roberts

Sonu Gandhi

Advances in clinical chemistry

临床化学卷的进展包含学术界和临床实验室科学领域领先专家的材料。这些评论涵盖了广泛的临床化学学科，包括临床生物标志物探索、尖端微阵列技术、蛋白质组学和基因组学。它是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Advances in Clinical Chemistry is a significant journal in the field of clinical chemistry, featuring contributions from leading experts in academia and clinical laboratory sciences. The reviews cover a wide range of topics in clinical chemistry, including the exploration of clinical biomarkers, cutting-edge microarray technologies, proteomics, and genomics. This journal serves as an indispensable resource and practical guide for professionals in clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences.

《Advances in Clinical Chemistry》是临床化学领域的重要期刊，涵盖了学术界和临床实验室科学领域的领先专家撰写的研究材料。这些评论涉及广泛的临床化学主题，包括临床生物标志物的探索、前沿的微阵列技术、蛋白质组学和基因组学。该期刊是临床化学、分子诊断学、病理学和临床实验室科学从业人员不可或缺的资源和实用指南。

Advances in Clinical Chemistry

Adv Clin Chem

Biosensor platforms for rapid HIV detection.

Nanosensor analytics including electrochemical, optical, piezoelectric, SERS-based lateral flow assay, microfluidic channel-based biosensors in the detection of HIV and other techniques in combination with different biorecognition elements (aptamers, antibodies, oligonucleotides) are discussed.

Category	Quartile
医学	2
医学, 医学实验技术	1

Biosensor platforms for rapid HIV detection.

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