Abstract: The small-molecular inhibitors targeted JAks (JAK inhibitors), could modulate the cytokines-mediated signaling via JAK-STAT pathway, which plays a important role in immune regulation and cell proliferation. The JAK inhibitors are previously designed and synthesized to treat diseases involved with hematologic and immune system. Increasing evidence shows that they are quite effective in atopic dermatitis (AD), alopecia areata (AA), psoriasis, vitiligo, and other autoimmune-induced dermatologic conditions. Currently, many JAK inhibitors possessing anti-vitiligo activity are being investigated in laboratory and clinically. In this view, we would like to summarize so we review the applications of these inhibitors with emphasis on profile of vitiligo, clinical efficacy, dosages, development of new candidates and adverse events through available literatures.

Chao Niu

Hunjun Xie

Haji Akber Aisa

Mini-Reviews in Medicinal Chemistry

MINI-REVIEWS IN MEDICINAL CHEMISTRY 的目的是发表关于药物化学和相关学科近期重要进展的简短评论。MINI-REVIEWS IN MEDICINAL CHEMISTRY 涵盖药物化学的所有领域，包括药物合理设计、合成化学、生物有机化学的发展, 高通量筛选, 组合化学, 药物靶点, 天然产物研究和构效关系研究。MINI-REVIEWS IN MEDICINAL CHEMISTRY 是每一位希望随时了解最新情况的药物和药物化学家的重要期刊。日期与最新和最重要的发展。

The purpose of Mini-Reviews in Medicinal Chemistry is to publish concise reviews on recent significant advances in medicinal chemistry and related disciplines. This journal covers all areas of medicinal chemistry, including rational drug design, synthetic chemistry, developments in bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, natural product research, and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for researchers who wish to stay updated on the latest and most important developments in the field.

《Mini-Reviews in Medicinal Chemistry》旨在发表关于药物化学及相关学科近期重要进展的简短评论。该期刊涵盖药物化学的各个领域，包括药物合理设计、合成化学、生物有机化学的发展、高通量筛选、组合化学、药物靶点、天然产物研究和构效关系研究。《Mini-Reviews in Medicinal Chemistry》是每位希望及时了解药物和药物化学最新进展的研究者的重要期刊。

Janus Kinase Inhibitors: A Review of Their Application in the Vitiligo

The small-molecular inhibitors targeted JAks (JAK inhibitors), could modulate the cytokines-mediated signaling via JAK-STAT pathway, which plays a important role in immune regulation and cell proliferation.

Category	Quartile
医学	3
医学, 药物化学	3

Janus Kinase Inhibitors: A Review of Their Application in the Vitiligo

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