Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people. The genetic basis of alcohol dependence concerning ethanol metabolism and the pathways of reward circuits are well known. The role of genetic variants in the neurobiology of addiction as well as in response to medication in alcoholism therapy still represents an intriguing argument that needs to be deeply analyzed and explained. The molecular approach to the study of these aspects could be difficult because of the large number of genes and variations involved. Our work is intended to offer an overview of genes and variants involved in alcohol addiction and pharmacogenetics. Our aim is to delineate a molecular approach strategy to look at alcohol dependence from a genetic and applicative point of view. The indications provided in this work should be of help for those who wish to undertake a molecular study of this multifactorial disease. Keywords: Alcohol addiction, genetic variants, neurobiology, pharmacogenetics, SNPs, therapy.

Giampiero Ferraguti

Esterina Pascale

Marco Lucarelli

Current Medicinal Chemistry

目标与范围当前药物化学涵盖药物化学和合理药物设计方面的所有最新和杰出发展。每期都包含一系列及时的深入评论和客座编辑的主题问题，这些问题由该领域的领导者撰写，涵盖了药物化学的一系列当前主题。该杂志还发表对近期专利的评论。 CURRENT MEDICINAL CHEMISTRY 是每一位希望随时了解最新和最重要进展的药物化学家的重要期刊。

Current Medicinal Chemistry covers all the latest and outstanding developments in the fields of medicinal chemistry and rational drug design. Each issue includes a series of timely in-depth reviews and guest-edited thematic issues written by leaders in the field, covering a range of current topics in medicinal chemistry. The journal also publishes reviews of recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to stay informed about the latest and most significant advancements.

《Current Medicinal Chemistry》涵盖了药物化学和合理药物设计领域的最新和杰出发展。每期都包含一系列及时的深入评论和由该领域领导者撰写的客座编辑主题问题，涉及药物化学的多个当前主题。此外，该杂志还发表对近期专利的评论。《Current Medicinal Chemistry》是每位希望了解药物化学领域最新和重要进展的研究者的重要期刊。

Category	Quartile
医学	4
医学, 生化与分子生物学	3
医学, 药物化学	3
医学, 药学	3

Alcohol Addiction: A Molecular Biology Perspective

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Journal Info

Category	Quartile
PHARMACOLOGY & PHARMACY	2