Stevens-Johnson syndrome (SJS) is a severe idiosyncratic reaction, most commonly triggered by medications, which is characterized by fever and mucocutaneous lesions, leading to necrosis and sloughing of the epidermis. Aside from skin and mucosal manifestations, SJS may also compromise heart, liver, kidney, lung, and gastrointestinal tract. Although cholestatic liver disease has been reported to occur in SJS, hepatic encephalopathy (HE) as a delayed complication has never been reported. We report a 4-year-old female child with anticonvulsant-induced SJS complicated by HE who was completely cured with a combination of systemic corticosteroid, intravenous immunoglobulin (IVIG), and plasmapheresis therapy. We suggested that plasmapheresis may be used as an adjuvant therapy for SJS with HE.

Po-Cheng Hung

Huei-Shyong Wang

Shao-Hsuan Hsia

Alex M-C Wong

Brain & development

BRAIN AND DEVELOPMENT (ISSN 0387-7604) 是日本儿童神经病学学会的官方期刊，旨在促进临床儿童神经病学和发育神经科学。该杂志致力于发表评论文章、完整的原始论文、病例报告和致儿童神经病学和相关科学领域编辑的信。会议记录和专业公告将由编辑酌情发表。也欢迎有关在《大脑与发展》上发表的文章和其他相关问题的来信。

Brain and Development (ISSN 0387-7604) is the official journal of the Japanese Society of Child Neurology, aimed at promoting clinical child neurology and developmental neuroscience. The journal publishes commentaries, full original research articles, case reports, and letters to the editors related to child neurology and related scientific fields. Conference proceedings and professional announcements will be published at the discretion of the editors. We also welcome correspondence regarding articles published in Brain and Development and other related matters.

《Brain and Development》（ISSN 0387-7604）是日本儿童神经病学学会的官方期刊，旨在促进临床儿童神经病学和发育神经科学的发展。该期刊发表评论文章、完整的原始研究论文、病例报告以及致儿童神经病学及相关科学领域编辑的信件。会议记录和专业公告将由编辑根据需要发表。同时，我们也欢迎关于在《Brain and Development》上发表的文章及其他相关问题的来信。

Brain and Development

Brain Dev

Plasmapheresis as adjuvant therapy in Stevens-Johnson syndrome and hepatic encephalopathy.

A 4-year-old female child with anticonvulsant-induced SJS complicated by HE who was completely cured with a combination of systemic corticosteroid, intravenous immunoglobulin (IVIG), and plasmapheresis therapy is reported.

Category	Quartile
医学	4
医学, 临床神经病学	4
医学, 儿科	4

Plasmapheresis as adjuvant therapy in Stevens-Johnson syndrome and hepatic encephalopathy.

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