Abstract A variety of chalcone derivatives were synthesized via aldol condensation of diverse aldehydes with acyclic and cyclic ketones, under mild reaction conditions. Reaction yields of pure products fluctuated from 48 % to 81 %. An unusually wide range of substrates including quinolines, thiophenes, pyridines, and fluorinated compounds were synthesized for this study. Full characterization data, along with in vitro antimicrobial activity for all adducts, are herein reported. Whole cell growth inhibition assays against staphylococcus aureus , escherichia coli , klebsiella pneumonia , a cinetobacter baumannii , pseudomonas aeruginosa , candida albicans and c ryptococcus neoformans var. grubii were performed employing all synthesized compounds ( 3a–m ).

Vikrant Patil

Enrique Barragan

Shivaputra A. Patil

Siddappa A. Patil

Alejandro Bugarin

ChemistrySelect

CHEMISTRYSELECT 是来自 CHEMPUBSOC EUROPE 和 WILEY-VCH 的最新期刊。它为研究人员提供了一份高质量的社会拥有的期刊，可以在其中发表他们在所有化学领域的工作。手稿由活跃的研究人员评估，以确保它们有意义地添加到科学文献中，并且对那些被接受的人进行快速处理，以确保快速在线发表。

CHEMISTRYSELECT is a new journal published by CHEMPUBSOC EUROPE and WILEY-VCH. It provides researchers with a high-quality, society-owned platform to publish their work across all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they make a meaningful contribution to the scientific literature, and accepted papers are processed quickly to ensure rapid online publication.

CHEMISTRYSELECT 是由 CHEMPUBSOC EUROPE 和 WILEY-VCH 出版的最新期刊。该期刊为研究人员提供了一个高质量的、由社会拥有的发表平台，涵盖所有化学领域的研究成果。所有提交的手稿均由活跃的研究人员进行评审，以确保其对科学文献的有意义贡献。被接受的稿件将快速处理，以确保能够迅速在线发表。

Direct Synthesis and Antimicrobial Evaluation of Structurally Complex Chalcones

A variety of chalcone derivatives were synthesized via aldol condensation of diverse aldehydes with acyclic and cyclic ketones, under mild reaction conditions, resulting in unusually wide range of substrates including quinolines, thiophenes, pyridines, and fluorinated compounds.

Category	Quartile
化学	4
化学, 化学综合	4

Direct Synthesis and Antimicrobial Evaluation of Structurally Complex Chalcones

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3