The pathogenesis underlining many neurodegenerative diseases remains incompletely understood. The lack of effective biomarkers and disease preventative medicine demands the development of new techniques to efficiently probe the mechanisms of disease and to detect early biomarkers predictive of disease onset. Raman spectroscopy is an established technique that allows the label-free fingerprinting and imaging of molecules based on their chemical constitution and structure. While analysis of isolated biological molecules has been widespread in the chemical community, applications of Raman spectroscopy to study clinically relevant biological species, disease pathogenesis, and diagnosis have been rapidly increasing since the past decade. The growing number of biomedical applications has shown the potential of Raman spectroscopy for detection of novel biomarkers that could enable the rapid and accurate screening of disease susceptibility and onset. Here we provide an overview of Raman spectroscopy and related techniques and their application to neurodegenerative diseases. We further discuss their potential utility in research, biomarker detection, and diagnosis. Challenges to routine use of Raman spectroscopy in the context of neuroscience research are also presented.

George Devitt

Kelly Howard

Amrit Mudher

Sumeet Mahajan

ACS Chemical Neuroscience

ACS 化学神经科学发表高质量的研究文章和评论，展示化学、定量生物学、生物物理和生物工程方法来理解神经系统和开发神经系统疾病的新疗法。该杂志的研究侧重于化学神经生物学和生物神经化学的各个方面，例如：神经递质和受体神经药物和治疗神经发育——可塑性和退化神经科学中的化学、物理和计算方法神经疾病——衰老的基础、检测和治疗机制、学习, 记忆和行为疼痛和感觉处理神经毒素神经科学启发的生物工程化学神经生物学方法的开发神经成像剂和技术中枢神经系统疾病的动物模型行为研究

ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biology, biophysical, and bioengineering approaches to understand the nervous system and develop new therapies for neurological diseases. The journal focuses on various aspects of chemical neurobiology and biochemistry, including neurotransmitters and receptors, neuropharmacology and therapies, neurodevelopment, plasticity and degeneration, chemical, physical, and computational methods in neuroscience, mechanisms of aging in neurological diseases, detection and treatment mechanisms, learning, memory and behavior, pain and sensory processing, neurotoxins, bioengineering inspired by neuroscience, development of chemical neurobiological methods, neuroimaging agents and techniques, as well as animal models and behavioral studies of central nervous system diseases.

《ACS Chemical Neuroscience》发表高质量的研究文章和评论，展示化学、定量生物学、生物物理学和生物工程方法，以理解神经系统并开发针对神经系统疾病的新疗法。该杂志的研究重点包括化学神经生物学和生物神经化学的各个方面，例如：神经递质与受体、神经药物与治疗、神经发育、可塑性与退化、神经科学中的化学、物理与计算方法、神经疾病的衰老机制、检测与治疗机制、学习、记忆与行为、疼痛与感觉处理、神经毒素、神经科学启发的生物工程、化学神经生物学方法的开发、神经成像剂与技术，以及中枢神经系统疾病的动物模型与行为研究。

Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis

An overview of Raman spectroscopy and related techniques and their application to neurodegenerative diseases is provided and their potential utility in research, biomarker detection, and diagnosis is discussed.

Category	Quartile
医学	3
医学, 生化与分子生物学	3
医学, 药物化学	3
医学, 神经科学	3

Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis

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