Relapse and metastasis are the major challenges that stand in the way of cancer healing and survival, mainly attributed to cancer stem cells (CSCs). Their capabilities of self-renewal and tumorigenic potential leads to treatment resistance development. CSCs function through signaling pathways such as the Wnt/β-catenin cascade. While commonly involved in embryogenesis and adult tissues homeostasis, the dysregulation of the Wnt pathway has direct correlations with tumorigenesis, metastasis, and drug resistance. The development of therapies that target CSCs and bulk tumors is both crucial and urgent. However, the extensive crosstalk present between Wnt and other signaling networks (Hedgehog and Notch) complicates the development of efficient long-term therapies with minimal side-effects on normal tissues. Despite the obstacles, the emergence of Wnt inhibitors and subsequent modulation of the signaling pathways would provide dynamic therapeutic approaches to impairing CSCs and reversing resistance mechanisms.

Sabina Iluta

Madalina Nistor

Sanda Buruiana

Delia Dima

Genes

GENES (ISSN 2073-4425) 是一本经过同行评审的国际开放获取期刊，为与基因、遗传学和基因组学相关的研究提供了一个高级论坛。它发表评论、研究文章、通讯和技术说明。论文的长度没有限制，我们鼓励科学家尽可能详细地发表他们的结果。

GENES (ISSN 2073-4425) is a peer-reviewed international open-access journal that provides a high-level forum for research related to genes, genetics, and genomics. It publishes comments, research articles, communications, and technical notes. There is no restriction on the length of papers, and we encourage scientists to present their results as comprehensively as possible.

《Genes》（ISSN 2073-4425）是一本经过同行评审的国际开放获取期刊，专注于基因、遗传学和基因组学相关研究。期刊为研究者提供了一个高级论坛，发表内容包括评论、研究文章、通讯和技术说明。论文长度没有限制，我们鼓励科学家尽可能详细地分享他们的研究成果。

Category	Quartile
生物学	3
生物学, 遗传学	3

Wnt Signaling Pathway in Tumor Biology

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Journal Info

Category	Quartile
GENETICS & HEREDITY	2