Cold EI improves all of the central GC-MS performance aspects, but even though it is known for providing enhanced molecular ions, it is important to realize that Cold EI mass spectra also include all of the standard EI fragment ions. Thus, Cold EI mass spectra are fully compatible with mass spectral libraries, such as NIST for sample identification. As a result, Cold EI mass spectra (unlike any other soft ionization method) provide highly effective identifications that are often better than those obtained with standard EI for a few reasons:1).Cold EI mass spectra with enhanced molecular ions typically provide higher identification probabilities than standard EI, even though scoring lower matching factors (false alternatives scores are lowered much more).2).The visually observed molecular ions further serve to confirm or reject the NIST library identifications.3).Molecular ions provide isotope abundances that serve with our TAMI software for automatic confirmation or rejection of the NIST library identification and provide an elemental formula in case the compound is not in the library.4).The Cold EI identification probability can be even higher than that of a mass spectrum with a perfect match of 999 that can be obtained by NIST library searching its own mass spectrum.5).The clear Cold EI molecular ion enables the use of the NIST library option of constraints search with the molecular ion that further significantly increases the identification probability. Our findings are demonstrated with mass spectra of hexadecane (n-C

Aviv Amirav

Benny Neumark

Oneg Elkabets

Tal Alon

Journal of the American Society for Mass Spectrometry

《美国质谱学会杂志》发表的研究论文涵盖了质谱的各个方面，涵盖了质谱可以发挥作用的科学探究领域。该杂志发表的论文范围广泛，涉及质量的基础和应用光谱学。基础科目包括仪器原理、设计和演示、气相离子的结构和化学性质、热力学性质研究、离子光谱学、化学动力学、电离机制、离子碎裂理论、簇离子和势能表面。除了全文之外，该期刊还提供通讯、应用笔记、账户和观点

The Journal of the American Society for Mass Spectrometry publishes research papers covering all aspects of mass spectrometry, including its applications in various scientific inquiries. The journal features a wide range of papers that encompass both fundamental and applied spectroscopy. Fundamental topics include principles of instrumentation, design and demonstration, structure and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, ionization mechanisms, ion fragmentation theory, cluster ions, and potential energy surfaces. In addition to full articles, the journal also offers communications, application notes, accounts, and viewpoints.

《Journal of the American Society for Mass Spectrometry》发表的研究论文涵盖质谱的各个方面，涉及质谱在科学研究中的广泛应用。该杂志的论文范围广泛，涵盖基础和应用光谱学。基础主题包括仪器原理、设计与演示、气相离子的结构与化学性质、热力学性质研究、离子光谱学、化学动力学、电离机制、离子碎裂理论、簇离子和势能表面等。此外，期刊还提供通讯、应用笔记、账户和观点等内容。

Category	Quartile
化学	2
化学, 光谱学	2
化学, 生化研究方法	3
化学, 分析化学	3
化学, 物理化学	3

NIST Library Identification Probabilities Are the Highest with Cold EI Mass Spectra

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