Abstract The sorbicillinoid family is a large class of natural products known for their structural variety and strong, diverse biological activities. A special member of this family, sorbicillactone A, the first nitrogen-containing sorbicillinoid, exhibits potent anti-leukemic and anti-HIV activities and possesses a unique structure formed from sorbicillinol, alanine, and fumaric acid building blocks. To facilitate in-depth biological and structure-activity relationship studies of this promising natural product, we developed a chemoenzymatic approach that provides access to sorbicillactone A and several analogs with excellent yields under precise stereochemical control. The key steps of the highly convergent, stereoselective, and short route are the enantioselective oxidative dearomatization of sorbillin to sorbicillinol catalyzed by the enzyme SorbC and the subsequent Michael addition of a fumarylazlactone building block. Additionally, our synthetic findings and bioinformatic analysis suggest that sorbicillactone A is biosynthetically formed analogously.

Jonas I Müller

Tobias A M Gulder

Communications Chemistry

COMMUNICATIONS CHEMISTRY 是 NATURE RESEARCH 的一本开放获取期刊，发表化学科学所有领域的高质量研究、评论和评论。该杂志发表的研究论文代表了重大进展，为专业研究领域带来了新的化学见解。我们还旨在为所有化学家的重要问题提供一个社区论坛，无论其子学科如何。

Communications Chemistry is an open-access journal published by NATURE RESEARCH, dedicated to high-quality research, reviews, and commentaries across all areas of chemical science. The research papers published in this journal represent significant advancements, providing new insights into the field of chemistry. We also aim to offer a community forum for all chemists to discuss important issues, regardless of their sub-discipline.

《Communications Chemistry》是NATURE RESEARCH旗下的一本开放获取期刊，致力于发表化学科学各个领域的高质量研究论文、评论和综述。该期刊所刊登的研究成果代表了重要的科学进展，为专业领域带来了新的化学见解。此外，我们还旨在为所有化学家提供一个讨论重要问题的社区论坛，无论其研究的子学科是什么。

Category	Quartile
化学	2
化学, 化学综合	2

Chemoenzymatic total synthesis of sorbicillactone A

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	1