Protein therapeutics based on transcription factors, gene editing enzymes, signaling proteins and protein antigens, have the potential to provide cures for a wide number of untreatable diseases, but cannot be developed into therapeutics due to challenges in delivering them into the cytoplasm. There is therefore great interest in developing strategies that can enable proteins to enter the cytoplasm of cells. In this review article we will discuss recent progress in intracellular protein therapeutics, which are focused on the following four classes of therapeutics, Firstly, vaccine development, secondly, transcription factor therapies, thirdly, gene editing and finally, cancer therapeutics. These exciting new advances raise the prospect of developing cures for several un-treatable diseases.

Yumiao Zhang

Joachim Justad Røise

Kunwoo Lee

Jie Li

Niren Murthy

Current opinion in biotechnology

CURRENT OPINION IN BIOTECHNOLOGY (COBIOT) 发表权威、全面和系统的评论。 COBIOT 帮助专家通过清晰易读的最新生物技术综合了解最新动态。专家作者从当今发布的不断扩大的信息量中注释最有趣的论文，从而节省宝贵的时间并让读者深入了解重要领域。

Current Opinion in Biotechnology (COBIOT) publishes authoritative, comprehensive, and systematic reviews. COBIOT assists experts in understanding the latest developments in biotechnology through clear and accessible overviews. Expert authors annotate the most interesting papers from the ever-expanding body of information published today, saving valuable time and providing readers with in-depth insights into important areas.

《Current Opinion in Biotechnology》（COBIOT）发表权威、全面且系统的评论。COBIOT帮助专家通过清晰易读的最新生物技术综述，了解行业动态。专家作者从当今不断扩大的信息中，挑选出最有趣的论文进行注释，从而节省宝贵的时间，并让读者深入了解重要领域。

Current Opinion in Biotechnology

Curr Opin Biotechnol

Recent developments in intracellular protein delivery.

Recent progress in intracellular protein therapeutics is discussed, which are focused on the following four classes of therapeutics, Firstly, vaccine development, secondly, transcription factor therapies, thirdly, gene editing and finally, cancer therapeutics.

Category	Quartile
工程技术	2
工程技术, 生化研究方法	1
工程技术, 生物工程与应用微生物	2

Recent developments in intracellular protein delivery.

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