Postoperative adhesions commonly cause severe complications, and also increase the risk of adhesiolysis. To improve postoperative adhesion, a series of 2-methacryloyloxy ethyl phosphorylcholine conjugated methylcellulose (MC-g-MPC) derivatives were synthesized to utilize the anti-protein adsorption of 2-methacryloyloxy ethyl phosphorylcholine and the thermosensitivity of methylcellulose. The structures of MC-g-MPC derivatives were characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) analyses, and their thermosensitivities were studied by rheological analysis. The gelling temperature of the MC-g-MPC hydrogel was 33 °C and gelling time of the hydrogel under body temperature was 2.5 min. The morphology of the MC-g-MPC hydrogel was observed by scanning electron microscopy (SEM). The results of in vitro cytotoxicity and immunotoxicity, and hemolysis assays demonstrated the good biocompatibility of MC-g-MPC hydrogels. Following the injection of the MC-g-MPC hydrogel, the postoperative adhesion of damaged ceca in Sprague-Dawley rats was improved when compared with a control group (no treatment). In addition, MC-g-MPC-0.25 hydrogel could downregulate the expression of Col-I and Col-IV collagen proteins, thus exert its antiprotein absorption capacity. Therefore, the MC-g-MPC hydrogel is a promising biomaterial for preventing postoperative adhesion. Yaqing Huang and Weihong Guo have contributed equally to this work.

Yaqing Huang

Weihong Guo

Junzhao Zhang

Xiao Peng

Guoxin Li

Li-Ming Zhang

Liqun Yang

Cellulose

CELLULOSE 是一份致力于传播纤维素和相关天然聚合物领域的研究和科技进步的国际期刊。该杂志关注纤维素及相关材料的纯科学和应用科学，以及相关新技术的发展。这包括纤维素及其来源的化学、生物化学、物理学和材料科学，包括木材和其他生物质资源及其衍生物。涵盖范围延伸到将这些聚合物和资源转化为制成品，例如纸浆、纸张、纺织品以及制成品和天然纤维，以及加工中使用的材料的化学性质。 CELLULOSE 发表评论文章、研究论文和技术说明。

Cellulose is an international journal dedicated to disseminating research and technological advancements in the field of cellulose and related natural polymers. The journal focuses on both fundamental and applied sciences related to cellulose and its associated materials, as well as the development of new technologies. This includes the chemistry, biochemistry, physics, and materials science of cellulose and its sources, encompassing wood, other biomass resources, and their derivatives. The scope extends to the conversion of these polymers and resources into products such as pulp, paper, textiles, and natural fibers, as well as the chemical properties of materials used in processing. Cellulose publishes commentaries, research articles, and technical notes.

《Cellulose》是一本国际期刊，致力于传播纤维素及相关天然聚合物领域的研究和科技进展。该期刊关注纤维素及其相关材料的基础科学和应用科学，以及新技术的发展。这包括纤维素及其来源的化学、生物化学、物理学和材料科学，涵盖木材、其他生物质资源及其衍生物。期刊的范围还扩展到将这些聚合物和资源转化为成品，例如纸浆、纸张、纺织品、天然纤维以及在加工中使用的材料的化学性质。《Cellulose》发表评论文章、研究论文和技术说明。

Thermosensitive hydrogels based on methylcellulose derivatives for prevention of postoperative adhesion

Following the injection of the MC-g-MPC hydrogel, the postoperative adhesion of damaged ceca in Sprague–Dawley rats was improved when compared with a control group (no treatment) and the results of in vitro cytotoxicity and immunotoxicity, and hemolysis assays demonstrated the good biocompatibility of MC-methacryloyloxy ethyl phosphorylcholine conjugated methylcellulose.

Category	Quartile
工程技术	2
工程技术, 材料科学纸与木材	1
工程技术, 材料科学纺织	1
工程技术, 高分子科学	2

Thermosensitive hydrogels based on methylcellulose derivatives for prevention of postoperative adhesion

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Journal Info

Category	Quartile
POLYMER SCIENCE	1