Aromatase inhibitors are the most used anticancer drug group in breast cancer cases. The development of resistance in cancer patients over time and the side effects of existing drugs make the need for new and effective agents permanent. In this study, 10 novel pyrimidine-triazole derivatives were synthesized and their anticancer activities were investigated. Compounds 5c and 5g showed inhibitor activity against MCF-7 cell line with IC50 =1.573±0.020; 3.698±0.056 μM value, respectively. As a result of in vitro aromatase enzyme inhibition test, compounds 5c and 5g were exhibited significant activity with IC50 =0.082±0.007 μM and IC50 =0.198±0.015 μM, respectively. Estimated physicochemical parameters were calculated using the online SwissADME program for all compounds. Interaction modes of the compounds 5c and 5g were investigated against aromatase enzyme by means of docking studies. As a result of the studies, the importance of the triazole ring for aromatase inhibition has been understood.

Derya Osmaniye

Arzu Hıdır

Begüm Nurpelin Sağlık

Serkan Levent

Yusuf Özkay

Zafer Asım Kaplancıklı

Chemistry & Biodiversity

化学与生物多样性是一个高质量的出版论坛，涵盖了广泛的生物相关主题，面向真正的国际受众。该杂志以完整的原创论文、简短的交流、特邀评论和评论的形式发表关于生物相关化学研究各个方面的特定领域和跨学科贡献。它涵盖了跨越化学和生物科学边界的所有研究领域，最终目标是拓宽我们对自然如何在分子水平上运作的理解。自 2017 年以来，《化学与生物多样性》以仅在线形式出版。

Chemistry and Biodiversity is a high-quality publication forum that covers a wide range of biology-related topics aimed at a truly international audience. The journal publishes original research articles, brief communications, invited reviews, and commentaries on various aspects of chemistry related to biological research, contributing to specific fields and interdisciplinary studies. It encompasses all research areas that cross the boundaries of chemistry and biological sciences, with the ultimate goal of broadening our understanding of how nature operates at the molecular level. Since 2017, Chemistry and Biodiversity has been published exclusively online.

《化学与生物多样性》是一个高质量的出版论坛，涵盖广泛的生物相关主题，面向国际受众。该杂志以完整的原创论文、简短的交流、特邀评论和综述的形式，发表关于生物相关化学研究各个方面的特定领域和跨学科的贡献。它涵盖了跨越化学和生物科学边界的所有研究领域，最终目标是拓宽我们对自然在分子水平上运作的理解。自2017年以来，《化学与生物多样性》仅以在线形式出版。

Chemistry and Biodiversity

Synthesis of New Pyrimidine‐Triazole Derivatives and Investigation of Their Anticancer Activities

10 novel pyrimidine‐triazole derivatives were synthesized and their anticancer activities were investigated, and the importance of the triazole ring for aromatase inhibition has been understood.

Category	Quartile
化学	3
化学, 化学综合	3
化学, 生化与分子生物学	4

Synthesis of New Pyrimidine‐Triazole Derivatives and Investigation of Their Anticancer Activities

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3