In this work, a series of novel indole 3-substituted- [1,2,4]triazole derivatives was designed and synthesized, and their structures were characterized by 1 H, 13 C NMR, high-resolution mass spectrometry, and single-crystal diffraction. Moreover, the antibacterial activities of the title compounds were evaluated against Xanthomonas oryzae pv. oryzae (Xoo), Pseudomonas syringae pv. actinidae (Psa), and Xanthomonas axonopodis pv. citri (Xac) by a turbidimetric method. Results showed that the title compounds had excellent bioactivity against Xoo, and their 50% effective concentration (EC 50 ) ranged from 2.32 to 35.4 µg/mL, which were better than those of the positive control drugs Bismerthiazol (38.6 µg/mL) and Thiodiazole-copper (58.4 µg/mL). In particular, the EC 50 values of compounds 53 and 9 against Xoo were 3.1 and 2.3 µg/mL, respectively.

Li Zhu

Si-Yu Tang

Dan-Ping Chen

Cheng-Peng Li

Li-Hui Shao

Gui-Ping Ouyang

Zhen-Chao Wang

Zhu-Rui Li

Chemical Papers

CHEMICAL PAPERS 是一本经过同行评审的国际期刊，致力于基础和应用化学研究。它涵盖化学科学的广泛范围，但有利于将化学与其他学科结合在一起的跨学科研究和研究。

Chemical Papers is a peer-reviewed international journal dedicated to fundamental and applied research in chemistry. It covers a wide range of chemical sciences, with a particular emphasis on interdisciplinary research that integrates chemistry with other disciplines.

《Chemical Papers》是一本经过同行评审的国际期刊，专注于基础和应用化学研究。期刊涵盖化学科学的广泛领域，特别鼓励跨学科的研究，促进化学与其他学科的结合。

Category	Quartile
化学	4
化学, 化学综合	4

Synthesis and antibacterial activity of indole 3-substituted-[1,2,4]triazole derivatives

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Journal Info

Category	Quartile
CHEMISTRY, MULTIDISCIPLINARY	3