Dendritic cells are major antigen-presenting cells (APC) that stimulate naA¯ve T cells, which induce adaptive immune responses. Gravesâ€™ disease (GD) is an autoimmune disease characterized by the presence of autoantibodies against Thyroid Stimulating Hormone Receptor (TSHR). The autoantibodies bind with TSHR and stimulate thyroid hormone production. Dendritic cells are still the major APC in GD immune response although thyrocytes in GD can also express Major Histocompatibility Class (MHC) class II molecule. Studies about DC in GD have been conducted by isolating intra-thyroid DC or DC in peripheral circulation. Results of DC studies in GD are still controversial. Changes in number and profile of DC are found, which indicate altered immune response activity and defects of regulator T cell (Treg) in GD. Key words : dendritic cells, Gravesâ€™ disease

Dyah Purnamasari

Pradana Soewondo

Samsuridjal Djauzi

Acta medica Indonesiana

Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine is an open accessed online journal and comprehensive peer-reviewed medical journal published by the Indonesian Society of Internal Medicine since 1968. Our main mission is to encourage the novel and important science in the clinical area in internal medicine.    We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of internal medicine.    Subjects suitable for publication include, but are not limited to the following fields of:    -Allergy and immunology  -Emergency medicine  -Cancer and stem cells  -Cardiovascular  -Endocrinology and Metabolism  -Gastroenterology  -Gerontology  -Hematology  -Hepatology  -Tropical and Infectious Disease  -Virology  -Internal medicine  -Psychosomatic  -Pulmonology  -Rheumatology  -Renal and Hypertension  -Thyroid

Acta Medica Indonesiana is an open-access online journal and a comprehensive peer-reviewed medical journal published by the Indonesian Society of Internal Medicine since 1968. Our main mission is to promote novel and significant scientific research in the clinical field of internal medicine. We welcome authors to submit original research articles, review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical aspects of internal medicine. Suitable subjects for publication include, but are not limited to, the following fields: Allergy and Immunology, Emergency Medicine, Cancer and Stem Cells, Cardiovascular, Endocrinology and Metabolism, Gastroenterology, Gerontology, Hematology, Hepatology, Tropical and Infectious Diseases, Virology, Internal Medicine, Psychosomatic Medicine, Pulmonology, Rheumatology, Renal and Hypertension, and Thyroid.

《Acta Medica Indonesiana》是由印度尼西亚内科学会自1968年起出版的开放获取在线期刊，致力于全面的同行评审医学研究。我们的主要使命是促进内科学领域的新颖和重要科学研究。我们欢迎作者提交原创研究文章、综述文章、有趣的病例报告、特别文章、临床实践和医学插图，重点关注内科学的临床领域。适合发表的主题包括但不限于以下领域：过敏与免疫学、急救医学、癌症与干细胞、心血管、内分泌与代谢、胃肠病学、老年医学、血液学、肝病学、热带与传染病、病毒学、内科学、心理生理学、肺病学、风湿病学、肾脏与高血压、甲状腺。

Dendritic Cells in Gravesâ€™ Disease

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Category	Quartile
MEDICINE, GENERAL & INTERNAL	3