We have developed a versatile synthetic approach for the synthesis of new isoindole derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo-cycloadduct prepared from the Diels-Alder reaction of furan and maleic anhydride furnished imide derivatives. The epoxide ring was opened with Ac 2 O in the presence of a catalytic amount of H 2 SO 4 in order to yield new isoindole derivatives (8a and 8b). The anticancer activity of these compounds was evaluated against MCF-7 (breast adenocarcinoma) and A549 (adenocarcinomic human alveolar basal epithelial) cell lines. The synthesized compounds showed concentration-and time-dependent inhibitory effects on the viability of both cell lines. Compound 8a was more toxic compared to 8b in both cancer cell lines, having higher cytotoxicity against A549 cells. Testing the toxicity properties of these compounds on the BEAS 2B (human bronchial epithelial) cell line indicated that while both compounds decreased the cell viability of cancer cells, they were less toxic on healthy lung cells. Microscopy images of A549 cells after treatment with the new isoindole derivatives displayed characteristic apoptotic morphology compared to BEAS 2B cells. The results demonstrated here suggest that these new compounds might be considered as possible potential anticancer agents for the treatment of lung and breast cancer.

Aytekin Köse

Yıldız Bal

Nurhan H. Kishalı

Gülşah Şanlı-Mohamed

Yunus Kara

Medicinal Chemistry Research

药物化学研究 (MCRE) 发表关于广泛主题的论文，有利于具有重要、新和最新信息的研究。尽管该期刊的同行评审过程要求很高，但 MCRE 仍然以快速发表而自豪，部分原因在于提交的长度。该杂志发表了关于各种主题的重要研究，其中许多强调分子生物学的结构-活性关系。

Medicinal Chemistry Research publishes research papers on a wide range of topics in the field of medicinal chemistry, aiming to provide important, novel, and up-to-date information. Although the peer-review process of the journal is rigorous, Medicinal Chemistry Research takes pride in its rapid publication, partly due to the relatively short length of submitted manuscripts. The journal covers significant research on various topics, many of which emphasize the structure-activity relationships in molecular biology.

《Medicinal Chemistry Research》发表关于药物化学领域的广泛主题的研究论文，旨在提供重要、新颖和最新的信息。尽管该期刊的同行评审过程要求严格，但《Medicinal Chemistry Research》仍以快速发表而自豪，这部分得益于提交论文的篇幅相对较短。期刊涵盖了多种主题的重要研究，许多研究强调了分子生物学中的结构-活性关系。

Synthesis and anticancer activity evaluation of new isoindole analogues

Testing the toxicity properties of these compounds on the BEAS 2B (human bronchial epithelial) cell line indicated that while both compounds decreased the cell viability of cancer cells, they were less toxic on healthy lung cells.

Category	Quartile
医学	4
医学, 药物化学	4

Synthesis and anticancer activity evaluation of new isoindole analogues

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	3