Endometriosis is a serious human gynecological disorder of women of reproductive age. The present study was designed to explore the therapeutic implications of rhein in the management of endometriosis. The results showed that rhein significantly (p<0.05) inhibited the proliferation of endometrial stroma cells in a dose-dependent fashion. Besides, the rhein treated endometrial stroma cells showed significantly (p<0.05) lower migration and invasion, in vitro. Transwell and wound healing assays showed that rhein also suppressed the migration and invasion of the endometrial stroma cells. Rhein was shown to target miR-135 at the molecular level to exert its anti-proliferative effects against the human endometrial stroma cells. Conversely, overexpression of miR-135 could nullify the anti-proliferative effects of rhein. Taken together, the findings of the present study highlight the therapeutic utility of rhein against human endometriosis. However, more in vivo studies are required.

Wang Dan

Zhang En Jing

Jiang Juan

Yang Yi

Jiang Yi Ling

Acta Biochimica Polonica

ACTA BIOCHIMICA POLONICA 是一本涵盖酶学和代谢、膜和生物能量学、基因结构和表达、蛋白质、核酸和碳水化合物结构和代谢的期刊。

Acta Biochimica Polonica is a professional journal that covers enzymology, metabolism, membrane biology and bioenergetics, gene structure and expression, as well as the structure and metabolism of proteins, nucleic acids, and carbohydrates.

《Acta Biochimica Polonica》是一本涵盖酶学、代谢、膜生物学和生物能量学、基因结构与表达、以及蛋白质、核酸和碳水化合物的结构与代谢的专业期刊。

Rhein inhibits endometriosis by targeting microRNA-135

Rhein was shown to target miR-135 at the molecular level to exert its anti-proliferative effects against the human endometrial stroma cells to highlight the therapeutic utility of rhein againsthuman endometriosis.

Category	Quartile
生物学	4
生物学, 生化与分子生物学	4

Rhein inhibits endometriosis by targeting microRNA-135

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Journal Info

Category	Quartile
BIOCHEMISTRY & MOLECULAR BIOLOGY	4