P53 protein is the product of P53 gene, which is a well acknowledged tumor suppressor gene. The function of P53 and the relevant mechanisms of anti-neoplasm have raised the interest of researchers since many years ago. It is demonstrated that P53 is a basic cell cycle regulator and a strong inhibitor for versatile cancers in humans. However, most research focuses on other organs and systems instead of the central nervous system (CNS). In fact, in recent years, more and more studies have been suggesting that P53 plays a significant role in multiple CNS tumors and other diseases and disorders such as cerebral stroke and neurodegenerative diseases. In this work, we mainly reviewed the P53’s relationship with CNS tumors, cerebral stroke and neurodegenerative diseases, together with the relevant mechanisms, aiming to summarize the research achievements and providing new insight to the future study on diseases in CNS.

Li Lei

Qixiong Lu

Guifang Ma

Tao Li

Jiahong Deng

Weijia Li

Frontiers in Genetics

FRONTIERS IN GENETICS 发表了经过严格同行评审的关于与生命的所有领域相关的基因和基因组的研究，从人类到植物，再到牲畜和其他模式生物。这本多学科、开放获取的期刊由世界领先专家组成的杰出编辑委员会领导，处于向研究人员、学者、临床医生、政策制定者和公众传播前沿研究的前沿。遗传研究及其影响各种生物过程的基因组有据可查。然而，大多数发现仍有待发现。一个新时代正在见证基因组功能和变异性、遗传和基因组工具的使用以及各种生物现象的遗传基础分析方面的重大发展。

Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes related to all fields of life, from humans to plants, livestock, and other model organisms. This multidisciplinary, open-access journal is led by a distinguished editorial board composed of world-leading experts, at the forefront of disseminating cutting-edge research to researchers, scholars, clinicians, policymakers, and the public. Genetic research and the genomic basis of its impact on various biological processes are well-documented; however, many discoveries remain to be made. We are witnessing a new era of significant advancements in the understanding of genomic functions and variability, the use of genetic and genomic tools, and the analysis of the genetic basis of various biological phenomena.

《Frontiers in Genetics》发表经过严格同行评审的研究，涵盖与生命相关的所有领域的基因和基因组，从人类到植物，再到牲畜和其他模式生物。这本多学科、开放获取的期刊由世界领先的专家组成的杰出编辑委员会领导，致力于向研究人员、学者、临床医生、政策制定者和公众传播前沿研究。遗传研究及其对各种生物过程的影响的基因组有据可查，但仍有许多发现待探索。我们正处于一个新时代，见证基因组功能和变异性、遗传和基因组工具的使用，以及对各种生物现象的遗传基础分析方面的重大进展。

P53 protein and the diseases in central nervous system

The P53’s relationship with CNS tumors, cerebral stroke and neurodegenerative diseases, together with the relevant mechanisms are reviewed, aiming to summarize the research achievements and provide new insight to the future study on diseases in CNS.

Category	Quartile
生物学	3
生物学, 遗传学	3

P53 protein and the diseases in central nervous system

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