Midinfrared photothermal (MIP) microscopy, also called optical photothermal infrared (O-PTIR) microscopy, is an emerging tool for bond-selective chemical imaging of living biological and material samples. In MIP microscopy, a visible probe beam detects the photothermal-based contrast induced by a vibrational absorption. With submicron spatial resolution, high spectral fidelity, and reduced water absorption background, MIP microscopy has overcome the limitations in infrared chemical imaging methods. In this review, we summarize the basic principle of MIP microscopy, the different origins of MIP contrasts, and recent technology development that pushed the resolution, speed, and sensitivity of MIP imaging to a new stage. We further emphasize its broad applications in life science and material characterization, and provide a perspective of future technical advances.

Qing Xia

Jiaze Yin

Zhongyue Guo

Ji-Xin Cheng

The Journal of Physical Chemistry B

期刊接受研究文章的一个基本标准是它们提供了新的物理见解。请参阅 NEW PHYSICAL INSIGHTS 虚拟问题，了解什么是新的物理洞察力。本质上报告数据或数据应用的手稿通常不适合在 JPC B 中发表。

The Journal of Physical Chemistry B accepts research articles based on the fundamental criterion of providing new physical insights. For what constitutes new physical insights, please refer to the NEW PHYSICAL INSIGHTS virtual issue. Manuscripts that primarily report data or data applications are generally not suitable for publication in the Journal of Physical Chemistry B.

《Journal of Physical Chemistry B》期刊接受研究文章的基本标准是提供新的物理见解。有关什么是新的物理洞察力，请参阅 NEW PHYSICAL INSIGHTS 虚拟问题。一般来说，仅报告数据或数据应用的手稿通常不适合在《Journal of Physical Chemistry B》上发表。

Journal of Physical Chemistry B

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

This review concludes that MIP microscopy has overcome the limitations in infrared chemical imaging methods and has broad applications in life science and material characterization, and provides a perspective of future technical advances.

Category	Quartile
化学	2
化学, 物理化学	3

Mid-Infrared Photothermal Microscopy: Principle, Instrumentation, and Applications

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