A fundamental limitation of potentiometric ion sensors is their relatively low sensitivity due to the logarithmic dependence between potential and activity. Here we address this issue by exploring a recently developed coulometric transduction method for solid-contact ion-selective electrodes (SCISEs). Spin-coated thin-layer ion-selective membranes are used to lower the membrane resistance and shorten the response time of the SCISEs. When using coulometric transduction, an optimized design of the K+-SCISE is able to detect a concentration change of 5 μM at a concentration level of 5 mM, corresponding to a 0.1% change in K+ activity. This indicates that SCISEs can provide extremely high sensitivity when employing coulometric transduction. Impedance measurements show that the coulometric transduction process for the K+-SCISE is limited by diffusion even for very thin ion-selective membranes. On the other hand, the H+-SCISE shows a low impedance and a fast coulometric response that is related to the high mobility of H+ in the H+-selective polymeric membrane as well as in the solid contact layer. The coulometric transduction method was used to detect small changes of pH in seawater and found to improve the sensitivity compared to classical potentiometry. The coulometric method was briefly tested also for determining activity changes of K+ in a serum sample.

Tingting Han

Ulriika Mattinen

Johan Bobacka

ACS Sensors

ACS SENSORS 是一份经过同行评审的研究期刊，致力于传播有关选择性感知化学或生物物种或过程的传感器科学各个方面的新知识和原创知识。文章可能涉及适用于多种类型分析物的传感概念进展，或报告以新方式或新分析物使用现有传感概念的应用论文。申请文件应展示传感器在复杂样品中的使用，证明其适用，并展示传感器性能与现有分析方法的相关性。论文可能侧重于传感器的商业化开发或开发用于提供新科学知识的传感器。文章可能完全是关于传感的理论，也可能报告实验结果。

ACS SENSORS is a peer-reviewed research journal dedicated to disseminating new and original knowledge in all aspects of sensor science related to the selective detection of chemical or biological species or processes. Articles may cover advancements in sensing concepts applicable to various analytes or report applications of existing sensing concepts using new approaches or analytes. Submitted manuscripts should demonstrate the use of sensors in complex samples, establish their applicability, and relate sensor performance to existing analytical methods. Papers may focus on the commercialization of sensors or the development of sensors aimed at providing new scientific insights. Articles may be purely theoretical regarding sensing or may report experimental results.

ACS SENSORS 是一本经过同行评审的研究期刊，专注于传播关于选择性感知化学或生物物种及其过程的传感器科学的最新研究成果和原创性知识。文章可能涉及适用于多种类型分析物的传感概念的进展，或报告以新方式或新分析物使用现有传感概念的应用研究。提交的论文应展示传感器在复杂样品中的应用，证明其适用性，并展示传感器性能与现有分析方法之间的相关性。论文可以专注于传感器的商业化开发，或开发用于提供新科学知识的传感器。文章内容可能完全是关于传感的理论研究，也可能报告实验结果。

Improving the Sensitivity of Solid-Contact Ion-Selective Electrodes by Using Coulometric Signal Transduction

The coulometric transduction method was used to detect small changes of pH in seawater and found to improve the sensitivity compared to classical potentiometry and for determining activity changes of K+ in a serum sample.

Category	Quartile
化学	1
化学, 分析化学	1
化学, 化学综合	2
化学, 纳米科技	2

Improving the Sensitivity of Solid-Contact Ion-Selective Electrodes by Using Coulometric Signal Transduction

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Category	Quartile
NANOSCIENCE & NANOTECHNOLOGY	1