Malaria is a major parasitic disease in tropical and sub-tropical regions. Pertaining to the sustaining resistance in malarial parasite against the available drugs, novel treatment options are the need of the hour. In this resolve recently, focus has shifted to finding the natural alternatives that possess anti-plasmodial activity for combatting malaria. Drawing on the text written in ancient scriptures and Ayurveda, natural compounds are now being screened for their therapeutic properties. Indole is one such natural compound, present in all living organisms, it displays a range of therapeutic activities including anticancer, anti-inflammatory, antimalarial etc. In this review, we have discussed various indole scaffold as well as the semi-synthetic drugs containing indole moiety that have been synthesized for malaria treatment.

Mehak Chauhan

Anjali Saxena

Biswajit Saha

European journal of medicinal chemistry

《欧洲药物化学杂志》是一本全球性期刊，发表关于药物化学各个方面的研究。它为发表原创论文提供了一个媒介，也欢迎评论性的论文。典型的论文将报告化合物的有机合成、表征和药理学评价。其他感兴趣的主题是药物设计、QSAR、分子建模、药物-受体相互作用、药物代谢的分子方面、前药合成和药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的洞察力，或阐明目标。

The European Journal of Medicinal Chemistry is a global journal that focuses on various aspects of medicinal chemistry. It provides a platform for the publication of original research papers and also welcomes review articles. Typical research papers report on the organic synthesis, characterization, and pharmacological evaluation of compounds. Other relevant topics include drug design, quantitative structure-activity relationships (QSAR), molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis, and drug targeting. The journal encourages manuscripts that demonstrate the rationale of the research, provide insights into compound design or mechanistic understanding, or clarify the objectives of the study.

《欧洲药物化学杂志》是一本全球性的期刊，专注于药物化学的各个方面。它为原创研究论文提供了一个发表平台，同时也欢迎评论性论文。典型的研究论文通常会报告化合物的有机合成、表征及药理学评估。其他相关主题包括药物设计、定量构效关系（QSAR）、分子建模、药物与受体的相互作用、药物代谢的分子机制、前药合成以及药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的深刻见解，或阐明研究目标。

European Journal of Medicinal Chemistry

Eur J Med Chem

An insight in anti-malarial potential of indole scaffold: A review.

Various indole scaffold as well as the semi-synthetic drugs containing indole moiety that have been synthesized for malaria treatment are discussed.

Category	Quartile
医学	2
医学, 药物化学	1

An insight in anti-malarial potential of indole scaffold: A review.

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Journal Info

Category	Quartile
CHEMISTRY, MEDICINAL	1