Recently, a new genetic code with 62 sense codons, coding for 21 amino acids, and only 2 termination codons has been identified in archaea. The authors argue that the appearance of this variant of the genetic code is due to the relatively recent and complete recoding of all UAG stop codons to codons encoding for pyrrolysine. I re-evaluate this discovery by presenting arguments that favour the early, i.e. ancestral, appearance of this variant of the genetic code during the origin of the genetic code itself. These arguments are capable of supporting that during the origin of the organization of the genetic code, at least two versions of the genetic code evolved in the domain of the Archaea. Thus, the genetic code would not be absolutely universal.

Massimo Di Giulio

Biosystems

BIOSYSTEMS 鼓励将生物学、进化思维和信息处理科学联系起来的实验、计算和理论文章。链接区域形成一个圆圈，涵盖生物信息处理的基本性质、复杂生物系统的计算建模、计算的进化模型、将生物学原理应用于新型计算系统的设计以及使用生物分子材料合成人工捕捉自然生物信息处理基本原理的系统。

The journal "BioSystems" encourages the integration of biology, evolutionary thinking, and information processing science, publishing experimental, computational, and theoretical articles. The scope of the journal encompasses the fundamental properties of biological information processing, computational modeling of complex biological systems, evolutionary models of computation, and the application of biological principles to the design of novel computational systems. Additionally, it focuses on artificial systems synthesized from biomolecular materials to capture the fundamental principles of natural biological information processing.

《BioSystems》期刊鼓励将生物学、进化思维与信息处理科学相结合，发表实验、计算和理论方面的研究文章。该期刊的研究领域涵盖生物信息处理的基本特性、复杂生物系统的计算建模、计算的进化模型，以及将生物学原理应用于新型计算系统的设计。此外，期刊还关注利用生物分子材料合成的人工系统，以捕捉自然生物信息处理的基本原理。

Category	Quartile
生物学	4
生物学, 生物学	4
生物学, 数学与计算生物学	4

The genetic code is not universal

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Journal Info

Category	Quartile
MATHEMATICAL & COMPUTATIONAL BIOLOGY	3